Using Steered Molecular Dynamics to Predict and Assess Hsp70 Substrate-Binding Domain Mutants that Alter Prion Propagation

Genetic screens using Saccharomyces cerevisiae have identified an array of cytosolic Hsp70 mutants that are impaired in the ability to propagate the yeast [PSI (+)] prion. The best characterized of these mutants is the Ssa1 L483W mutant (so-called SSA1-21), which is located in the substrate-binding...

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Detalles Bibliográficos
Autores principales: Xu, Linan, Hasin, Naushaba, Shen, Manli, He, Jianwei, Xue, Youlin, Zhou, Xiaohong, Perrett, Sarah, Song, Youtao, Jones, Gary W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561046/
https://www.ncbi.nlm.nih.gov/pubmed/23382668
http://dx.doi.org/10.1371/journal.pcbi.1002896

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