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An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development

Harnessing genetic differences between cancerous and noncancerous cells offers a strategy for the development of new therapies. Extrapolating from yeast genetic interaction data, we used cultured human cells and siRNA to construct and evaluate a synthetic lethal interaction network comprised of chro...

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Detalles Bibliográficos
Autores principales:	van Pel, Derek M., Barrett, Irene J., Shimizu, Yoko, Sajesh, Babu V., Guppy, Brent J., Pfeifer, Tom, McManus, Kirk J., Hieter, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561056/ https://www.ncbi.nlm.nih.gov/pubmed/23382697 http://dx.doi.org/10.1371/journal.pgen.1003254

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