Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers

Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans using two approaches. After isolating IgG from human plasma, we performed 77 quantitative me...

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Detalles Bibliográficos
Autores principales: Lauc, Gordan, Huffman, Jennifer E., Pučić, Maja, Zgaga, Lina, Adamczyk, Barbara, Mužinić, Ana, Novokmet, Mislav, Polašek, Ozren, Gornik, Olga, Krištić, Jasminka, Keser, Toma, Vitart, Veronique, Scheijen, Blanca, Uh, Hae-Won, Molokhia, Mariam, Patrick, Alan Leslie, McKeigue, Paul, Kolčić, Ivana, Lukić, Ivan Krešimir, Swann, Olivia, van Leeuwen, Frank N., Ruhaak, L. Renee, Houwing-Duistermaat, Jeanine J., Slagboom, P. Eline, Beekman, Marian, de Craen, Anton J. M., Deelder, André M., Zeng, Qiang, Wang, Wei, Hastie, Nicholas D., Gyllensten, Ulf, Wilson, James F., Wuhrer, Manfred, Wright, Alan F., Rudd, Pauline M., Hayward, Caroline, Aulchenko, Yurii, Campbell, Harry, Rudan, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561084/
https://www.ncbi.nlm.nih.gov/pubmed/23382691
http://dx.doi.org/10.1371/journal.pgen.1003225

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