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African Programme for Onchocerciasis Control 1995–2015: Model-Estimated Health Impact and Cost

BACKGROUND: Onchocerciasis causes a considerable disease burden in Africa, mainly through skin and eye disease. Since 1995, the African Programme for Onchocerciasis Control (APOC) has coordinated annual mass treatment with ivermectin in 16 countries. In this study, we estimate the health impact of A...

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Autores principales: Coffeng, Luc E., Stolk, Wilma A., Zouré, Honorat G. M., Veerman, J. Lennert, Agblewonu, Koffi B., Murdoch, Michele E., Noma, Mounkaila, Fobi, Grace, Richardus, Jan Hendrik, Bundy, Donald A. P., Habbema, Dik, de Vlas, Sake J., Amazigo, Uche V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561133/
https://www.ncbi.nlm.nih.gov/pubmed/23383355
http://dx.doi.org/10.1371/journal.pntd.0002032
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author Coffeng, Luc E.
Stolk, Wilma A.
Zouré, Honorat G. M.
Veerman, J. Lennert
Agblewonu, Koffi B.
Murdoch, Michele E.
Noma, Mounkaila
Fobi, Grace
Richardus, Jan Hendrik
Bundy, Donald A. P.
Habbema, Dik
de Vlas, Sake J.
Amazigo, Uche V.
author_facet Coffeng, Luc E.
Stolk, Wilma A.
Zouré, Honorat G. M.
Veerman, J. Lennert
Agblewonu, Koffi B.
Murdoch, Michele E.
Noma, Mounkaila
Fobi, Grace
Richardus, Jan Hendrik
Bundy, Donald A. P.
Habbema, Dik
de Vlas, Sake J.
Amazigo, Uche V.
author_sort Coffeng, Luc E.
collection PubMed
description BACKGROUND: Onchocerciasis causes a considerable disease burden in Africa, mainly through skin and eye disease. Since 1995, the African Programme for Onchocerciasis Control (APOC) has coordinated annual mass treatment with ivermectin in 16 countries. In this study, we estimate the health impact of APOC and the associated costs from a program perspective up to 2010 and provide expected trends up to 2015. METHODS AND FINDINGS: With data on pre-control prevalence of infection and population coverage of mass treatment, we simulated trends in infection, blindness, visual impairment, and severe itch using the micro-simulation model ONCHOSIM, and estimated disability-adjusted life years (DALYs) lost due to onchocerciasis. We assessed financial costs for APOC, beneficiary governments, and non-governmental development organizations, excluding cost of donated drugs. We estimated that between 1995 and 2010, mass treatment with ivermectin averted 8.2 million DALYs due to onchocerciasis in APOC areas, at a nominal cost of about US$257 million. We expect that APOC will avert another 9.2 million DALYs between 2011 and 2015, at a nominal cost of US$221 million. CONCLUSIONS: Our simulations suggest that APOC has had a remarkable impact on population health in Africa between 1995 and 2010. This health impact is predicted to double during the subsequent five years of the program, through to 2015. APOC is a highly cost-effective public health program. Given the anticipated elimination of onchocerciasis from some APOC areas, we expect even more health gains and a more favorable cost-effectiveness of mass treatment with ivermectin in the near future.
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spelling pubmed-35611332013-02-04 African Programme for Onchocerciasis Control 1995–2015: Model-Estimated Health Impact and Cost Coffeng, Luc E. Stolk, Wilma A. Zouré, Honorat G. M. Veerman, J. Lennert Agblewonu, Koffi B. Murdoch, Michele E. Noma, Mounkaila Fobi, Grace Richardus, Jan Hendrik Bundy, Donald A. P. Habbema, Dik de Vlas, Sake J. Amazigo, Uche V. PLoS Negl Trop Dis Research Article BACKGROUND: Onchocerciasis causes a considerable disease burden in Africa, mainly through skin and eye disease. Since 1995, the African Programme for Onchocerciasis Control (APOC) has coordinated annual mass treatment with ivermectin in 16 countries. In this study, we estimate the health impact of APOC and the associated costs from a program perspective up to 2010 and provide expected trends up to 2015. METHODS AND FINDINGS: With data on pre-control prevalence of infection and population coverage of mass treatment, we simulated trends in infection, blindness, visual impairment, and severe itch using the micro-simulation model ONCHOSIM, and estimated disability-adjusted life years (DALYs) lost due to onchocerciasis. We assessed financial costs for APOC, beneficiary governments, and non-governmental development organizations, excluding cost of donated drugs. We estimated that between 1995 and 2010, mass treatment with ivermectin averted 8.2 million DALYs due to onchocerciasis in APOC areas, at a nominal cost of about US$257 million. We expect that APOC will avert another 9.2 million DALYs between 2011 and 2015, at a nominal cost of US$221 million. CONCLUSIONS: Our simulations suggest that APOC has had a remarkable impact on population health in Africa between 1995 and 2010. This health impact is predicted to double during the subsequent five years of the program, through to 2015. APOC is a highly cost-effective public health program. Given the anticipated elimination of onchocerciasis from some APOC areas, we expect even more health gains and a more favorable cost-effectiveness of mass treatment with ivermectin in the near future. Public Library of Science 2013-01-31 /pmc/articles/PMC3561133/ /pubmed/23383355 http://dx.doi.org/10.1371/journal.pntd.0002032 Text en © 2013 Coffeng et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Coffeng, Luc E.
Stolk, Wilma A.
Zouré, Honorat G. M.
Veerman, J. Lennert
Agblewonu, Koffi B.
Murdoch, Michele E.
Noma, Mounkaila
Fobi, Grace
Richardus, Jan Hendrik
Bundy, Donald A. P.
Habbema, Dik
de Vlas, Sake J.
Amazigo, Uche V.
African Programme for Onchocerciasis Control 1995–2015: Model-Estimated Health Impact and Cost
title African Programme for Onchocerciasis Control 1995–2015: Model-Estimated Health Impact and Cost
title_full African Programme for Onchocerciasis Control 1995–2015: Model-Estimated Health Impact and Cost
title_fullStr African Programme for Onchocerciasis Control 1995–2015: Model-Estimated Health Impact and Cost
title_full_unstemmed African Programme for Onchocerciasis Control 1995–2015: Model-Estimated Health Impact and Cost
title_short African Programme for Onchocerciasis Control 1995–2015: Model-Estimated Health Impact and Cost
title_sort african programme for onchocerciasis control 1995–2015: model-estimated health impact and cost
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561133/
https://www.ncbi.nlm.nih.gov/pubmed/23383355
http://dx.doi.org/10.1371/journal.pntd.0002032
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