Dissection of Ire1 Functions Reveals Stress Response Mechanisms Uniquely Evolved in Candida glabrata

Proper protein folding in the endoplasmic reticulum (ER) is vital in all eukaryotes. When misfolded proteins accumulate in the ER lumen, the transmembrane kinase/endoribonuclease Ire1 initiates splicing of HAC1 mRNA to generate the bZIP transcription factor Hac1, which subsequently activates its tar...

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Detalles Bibliográficos
Autores principales: Miyazaki, Taiga, Nakayama, Hironobu, Nagayoshi, Yohsuke, Kakeya, Hiroshi, Kohno, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561209/
https://www.ncbi.nlm.nih.gov/pubmed/23382685
http://dx.doi.org/10.1371/journal.ppat.1003160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561209/
https://www.ncbi.nlm.nih.gov/pubmed/23382685
http://dx.doi.org/10.1371/journal.ppat.1003160

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