Trypanosoma cruzi Response to Sterol Biosynthesis Inhibitors: Morphophysiological Alterations Leading to Cell Death

The protozoan parasite Trypanosoma cruzi displays similarities to fungi in terms of its sterol lipid biosynthesis, as ergosterol and other 24-alkylated sterols are its principal endogenous sterols. The sterol pathway is thus a potential drug target for the treatment of Chagas disease. We describe he...

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Detalles Bibliográficos
Autores principales: Kessler, Rafael Luis, Soares, Maurilio José, Probst, Christian Macagnan, Krieger, Marco Aurélio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561218/
https://www.ncbi.nlm.nih.gov/pubmed/23383204
http://dx.doi.org/10.1371/journal.pone.0055497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561218/
https://www.ncbi.nlm.nih.gov/pubmed/23383204
http://dx.doi.org/10.1371/journal.pone.0055497

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