Cargando…

In Vitro Blood-Brain Barrier Models Using Brain Capillary Endothelial Cells Isolated from Neonatal and Adult Rats Retain Age-Related Barrier Properties

The blood–brain barrier (BBB) restricts the entry of circulating drugs and xenobiotics into the brain, and thus its permeability to substances is a critical factor that determines their central effects. The infant brain is vulnerable to neurotoxic substances partly due to the immature BBB. The emplo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takata, Fuyuko, Dohgu, Shinya, Yamauchi, Atsushi, Matsumoto, Junichi, Machida, Takashi, Fujishita, Kayoko, Shibata, Keisuke, Shinozaki, Youichi, Sato, Kaoru, Kataoka, Yasufumi, Koizumi, Schuichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561369/ https://www.ncbi.nlm.nih.gov/pubmed/23383092 http://dx.doi.org/10.1371/journal.pone.0055166

Ejemplares similares

Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model
por: Machida, Takashi, et al.
Publicado: (2017)

Brain-transportable dipeptides across the blood-brain barrier in mice
por: Tanaka, Mitsuru, et al.
Publicado: (2019)

Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro
por: Takata, Fuyuko, et al.
Publicado: (2011)

Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice
por: Iwao, Takuro, et al.
Publicado: (2023)

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction
por: Takata, Fuyuko, et al.
Publicado: (2021)

Edaravone Protects against Methylglyoxal-Induced Barrier Damage in Human Brain Endothelial Cells
por: Tóth, Andrea E., et al.
Publicado: (2014)

The Astrocyte-Targeted Therapy by Bushi for the Neuropathic Pain in Mice
por: Shibata, Keisuke, et al.
Publicado: (2011)

Astrocytes Protect Neurons against Methylmercury via ATP/P2Y(1) Receptor-Mediated Pathways in Astrocytes
por: Noguchi, Yusuke, et al.
Publicado: (2013)

Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide(25-35)-induced memory impairment in mice
por: Tanaka, Mitsuru, et al.
Publicado: (2020)

The Neuroinflammatory Role of Pericytes in Epilepsy
por: Yamanaka, Gaku, et al.
Publicado: (2021)

Increased Plasma VEGF Levels in Patients with Cerebral Large Artery Disease Are Associated with Cerebral Microbleeds
por: Ogata, Toshiyasu, et al.
Publicado: (2019)

Upregulation of P2Y2 receptors by retinoids in normal human epidermal keratinocytes
por: Fujishita, Kayoko, et al.
Publicado: (2006)

Regulation of cell-to-cell communication mediated by astrocytic ATP in the CNS
por: Koizumi, Schuichi, et al.
Publicado: (2005)

A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration
por: Cheng, Lihong, et al.
Publicado: (2023)

Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood–brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk
por: Dohgu, Shinya, et al.
Publicado: (2013)

Astrocyte Immune Functions and Glaucoma
por: Shinozaki, Youichi, et al.
Publicado: (2023)

Human Immunodeficiency Virus-1 Uses the Mannose-6-Phosphate Receptor to Cross the Blood-Brain Barrier
por: Dohgu, Shinya, et al.
Publicado: (2012)

Alpha Adrenergic Induction of Transport of Lysosomal Enzyme across the Blood-Brain Barrier
por: Urayama, Akihiko, et al.
Publicado: (2015)

Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes
por: Kinoshita, Manao, et al.
Publicado: (2018)

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF
por: Dohgu, Shinya, et al.
Publicado: (2011)

Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis
por: Nishioku, Tsuyoshi, et al.
Publicado: (2012)

Transfection of brain capillary endothelial cells in primary culture with defined blood–brain barrier properties
por: Burkhart, Annette, et al.
Publicado: (2015)

Brain-Specific Ultrastructure of Capillary Endothelial Glycocalyx and Its Possible Contribution for Blood Brain Barrier
por: Ando, Yoshiaki, et al.
Publicado: (2018)

MAP Kinase Pathways in Brain Endothelial Cells and Crosstalk with Pericytes and Astrocytes Mediate Contrast-Induced Blood–Brain Barrier Disruption
por: Matsunaga, Yuki, et al.
Publicado: (2021)

Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries
por: Olivera, Gabriela C, et al.
Publicado: (2021)

Direct Observation of ATP-Induced Conformational Changes in Single P2X(4) Receptors
por: Shinozaki, Youichi, et al.
Publicado: (2009)

Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission
por: Shinozaki, Youichi, et al.
Publicado: (2014)

Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice
por: Matsuo, Taira, et al.
Publicado: (2022)

Strategies for Manipulating Microglia to Determine Their Role in the Healthy and Diseased Brain
por: Parajuli, Bijay, et al.
Publicado: (2022)

Development of a three-dimensional blood-brain barrier network with opening capillary structures for drug transport screening assays
por: Piantino, Marie, et al.
Publicado: (2022)

Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier
por: McCarthy, Ryan C., et al.
Publicado: (2015)

Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes
Publicado: (1994)

Uptake Mechanism of ApoE-Modified Nanoparticles on Brain Capillary Endothelial Cells as a Blood-Brain Barrier Model
por: Wagner, Sylvia, et al.
Publicado: (2012)

The Mlc1 Promoter Directs Müller Cell-specific Gene Expression in the Retina
por: Danjo, Yosuke, et al.
Publicado: (2022)

Abnormal Ca(2+) Signals in Reactive Astrocytes as a Common Cause of Brain Diseases
por: Koizumi, Schuichi, et al.
Publicado: (2021)

Evaluation of arsenic metabolism and tight junction injury after exposure to arsenite and monomethylarsonous acid using a rat in vitro blood–Brain barrier model
por: Yamauchi, Hiroshi, et al.
Publicado: (2023)

Characteristics of (L)-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells)
por: Lee, Kyeong-Eun, et al.
Publicado: (2017)

Barrier mechanisms in the Drosophila blood-brain barrier
por: Hindle, Samantha J., et al.
Publicado: (2014)

Loss of capillary pericytes and the blood–brain barrier in white matter in poststroke and vascular dementias and Alzheimer’s disease
por: Ding, Ren, et al.
Publicado: (2020)

Control of blood capillary networks and holes in blood-brain barrier models by regulating elastic modulus of scaffolds
por: Shang, Yucheng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_h3c44mdp36nur19pga77flj23g