Determining Antibody-Binding Site of Streptococcal Pyrogenic Exotoxin B to Protect Mice from Group A Streptococcus Infection

Streptococcal pyrogenic exotoxin B (SPE B), a cysteine protease, is an important virulence factor in group A streptococcal (GAS) infection. SPE B binds and cleaves antibody isotypes and further impairs the immune system by inhibiting complement activation. In this study, we examined the antibody-bin...

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Detalles Bibliográficos
Autores principales: Tsao, Nina, Cheng, Miao-Hui, Yang, Hsiu-Chen, Wang, Yu-Chieh, Liu, Yi-Ling, Kuo, Chih-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561455/
https://www.ncbi.nlm.nih.gov/pubmed/23383045
http://dx.doi.org/10.1371/journal.pone.0055028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561455/
https://www.ncbi.nlm.nih.gov/pubmed/23383045
http://dx.doi.org/10.1371/journal.pone.0055028

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