Towards germline gene therapy of inherited mitochondrial diseases

Mutations in mitochondrial DNA (mtDNA) are associated with serious human diseases and inherited from mother's eggs. Here we investigated the feasibility of mtDNA replacement in human oocytes by spindle transfer (ST). Of 106 human oocytes donated for research, 65 were subjected to reciprocal ST...

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Detalles Bibliográficos
Autores principales: Tachibana, Masahito, Amato, Paula, Sparman, Michelle, Woodward, Joy, Sanchis, Dario Melguizo, Ma, Hong, Gutierrez, Nuria Marti, Tippner-Hedges, Rebecca, Kang, Eunju, Lee, Hyo-Sang, Ramsey, Cathy, Masterson, Keith, Battaglia, David, Lee, David, Wu, Diana, Jensen, Jeffrey, Patton, Phillip, Gokhale, Sumita, Stouffer, Richard, Mitalipov, Shoukhrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561483/
https://www.ncbi.nlm.nih.gov/pubmed/23103867
http://dx.doi.org/10.1038/nature11647

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