Novel genetically-humanized mouse model established to evaluate efficacy of therapeutic agents to human interleukin-6 receptor

For clinical trials of therapeutic monoclonal antibodies (mAbs) to be successful, their efficacy needs to be adequately evaluated in preclinical experiments. However, in many cases it is difficult to evaluate the candidate mAbs using animal disease models because of lower cross-reactivity to the ort...

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Detalles Bibliográficos
Autores principales: Ueda, Otoya, Tateishi, Hiromi, Higuchi, Yoshinobu, Fujii, Etsuko, Kato, Atsuhiko, Kawase, Yosuke, Wada, Naoko A., Tachibe, Takanori, Kakefuda, Mami, Goto, Chisato, Kawaharada, Makoto, Shimaoka, Shin, Hattori, Kunihiro, Jishage, Kou-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561642/
https://www.ncbi.nlm.nih.gov/pubmed/23378927
http://dx.doi.org/10.1038/srep01196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561642/
https://www.ncbi.nlm.nih.gov/pubmed/23378927
http://dx.doi.org/10.1038/srep01196

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