Knockdown of clusterin sensitizes pancreatic cancer cells to gemcitabine chemotherapy by ERK1/2 inactivation

OBJECTIVES: To study the hypothesis that gemcitabine treatment augments the chemoresistance to gemcitabine by clusterin (sCLU) upregulation. Clusterin inhibition could augment the chemosensitivity of human pancreatic cancer cells by inhibition of clusterin-dependent pERK1/2 activation. METHODS: Clus...

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Detalles Bibliográficos
Autores principales: Tang, Yong, Liu, Fenghua, Zheng, Chunning, Sun, Shaochuan, Jiang, Yingsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561651/
https://www.ncbi.nlm.nih.gov/pubmed/22967941
http://dx.doi.org/10.1186/1756-9966-31-73

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561651/
https://www.ncbi.nlm.nih.gov/pubmed/22967941
http://dx.doi.org/10.1186/1756-9966-31-73

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