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Renal pericytes: regulators of medullary blood flow

Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli. DVR are composed of a continuous endothelium, intercalated with...

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Autores principales: Kennedy-Lydon, T M, Crawford, C, Wildman, S S P, Peppiatt-Wildman, C M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561688/
https://www.ncbi.nlm.nih.gov/pubmed/23126245
http://dx.doi.org/10.1111/apha.12026
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author Kennedy-Lydon, T M
Crawford, C
Wildman, S S P
Peppiatt-Wildman, C M
author_facet Kennedy-Lydon, T M
Crawford, C
Wildman, S S P
Peppiatt-Wildman, C M
author_sort Kennedy-Lydon, T M
collection PubMed
description Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli. DVR are composed of a continuous endothelium, intercalated with smooth muscle-like cells called pericytes. Pericytes have been shown to alter the diameter of isolated and in situ DVR in response to vasoactive stimuli that are transmitted via a network of autocrine and paracrine signalling pathways. Vasoactive stimuli can be released by neighbouring tubular epithelial, endothelial, red blood cells and neuronal cells in response to changes in NaCl transport and oxygen tension. The experimentally described sensitivity of pericytes to these stimuli strongly suggests their leading role in the phenomenon of MBF autoregulation. Because the debate on autoregulation of MBF fervently continues, we discuss the evidence favouring a physiological role for pericytes in the regulation of MBF and describe their potential role in tubulo-vascular cross-talk in this region of the kidney. Our review also considers current methods used to explore pericyte activity and function in the renal medulla.
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spelling pubmed-35616882013-02-01 Renal pericytes: regulators of medullary blood flow Kennedy-Lydon, T M Crawford, C Wildman, S S P Peppiatt-Wildman, C M Acta Physiol (Oxf) Reviews Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli. DVR are composed of a continuous endothelium, intercalated with smooth muscle-like cells called pericytes. Pericytes have been shown to alter the diameter of isolated and in situ DVR in response to vasoactive stimuli that are transmitted via a network of autocrine and paracrine signalling pathways. Vasoactive stimuli can be released by neighbouring tubular epithelial, endothelial, red blood cells and neuronal cells in response to changes in NaCl transport and oxygen tension. The experimentally described sensitivity of pericytes to these stimuli strongly suggests their leading role in the phenomenon of MBF autoregulation. Because the debate on autoregulation of MBF fervently continues, we discuss the evidence favouring a physiological role for pericytes in the regulation of MBF and describe their potential role in tubulo-vascular cross-talk in this region of the kidney. Our review also considers current methods used to explore pericyte activity and function in the renal medulla. Blackwell Publishing Ltd 2013-02 2012-11-06 /pmc/articles/PMC3561688/ /pubmed/23126245 http://dx.doi.org/10.1111/apha.12026 Text en Copyright © 2013 Scandinavian Physiological Society http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Reviews
Kennedy-Lydon, T M
Crawford, C
Wildman, S S P
Peppiatt-Wildman, C M
Renal pericytes: regulators of medullary blood flow
title Renal pericytes: regulators of medullary blood flow
title_full Renal pericytes: regulators of medullary blood flow
title_fullStr Renal pericytes: regulators of medullary blood flow
title_full_unstemmed Renal pericytes: regulators of medullary blood flow
title_short Renal pericytes: regulators of medullary blood flow
title_sort renal pericytes: regulators of medullary blood flow
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561688/
https://www.ncbi.nlm.nih.gov/pubmed/23126245
http://dx.doi.org/10.1111/apha.12026
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