Development of a Hypersensitive Periodate-Cleavable Amino Acid that is Methionine- and Disulfide-Compatible and its Application in MHC Exchange Reagents for T Cell Characterisation

Incorporation of cleavable linkers into peptides and proteins is of particular value in the study of biological processes. Here we describe the synthesis of a cleavable linker that is hypersensitive to oxidative cleavage as the result of the periodate reactivity of a vicinal amino alcohol moiety. Tw...

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Detalles Bibliográficos
Autores principales: Amore, Alessia, Wals, Kim, Koekoek, Evelyn, Hoppes, Rieuwert, Toebes, Mireille, Schumacher, Ton N M, Rodenko, Boris, Ovaa, Huib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561698/
https://www.ncbi.nlm.nih.gov/pubmed/23280887
http://dx.doi.org/10.1002/cbic.201200540

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