HIV-1 frameshift efficiency is primarily determined by the stability of base pairs positioned at the mRNA entrance channel of the ribosome

The human immunodeficiency virus (HIV) requires a programmed −1 ribosomal frameshift for Pol gene expression. The HIV frameshift site consists of a heptanucleotide slippery sequence (UUUUUUA) followed by a spacer region and a downstream RNA stem–loop structure. Here we investigate the role of the RN...

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Detalles Bibliográficos
Autores principales: Mouzakis, Kathryn D., Lang, Andrew L., Vander Meulen, Kirk A., Easterday, Preston D., Butcher, Samuel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561942/
https://www.ncbi.nlm.nih.gov/pubmed/23248007
http://dx.doi.org/10.1093/nar/gks1254

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