A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A

Replication protein A (RPA), essential for DNA replication, repair and DNA damage signalling, possesses six ssDNA-binding domains (DBDs), including DBD-F on the N-terminus of the largest subunit, RPA70. This domain functions as a binding site for p53 and other DNA damage and repair proteins that con...

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Detalles Bibliográficos
Autores principales: Glanzer, Jason G., Carnes, Katie A., Soto, Patricia, Liu, Shengqin, Parkhurst, Lawrence J., Oakley, Gregory G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561959/
https://www.ncbi.nlm.nih.gov/pubmed/23267009
http://dx.doi.org/10.1093/nar/gks1291

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