Cargando…

High-throughput sequence analysis reveals structural diversity and improved potency among RNA inhibitors of HIV reverse transcriptase

Systematic evolution of ligands through exponential enrichment (SELEX) is a well-established method for generating nucleic acid populations that are enriched for specified functions. High-throughput sequencing (HTS) enhances the power of comparative sequence analysis to reveal details of how RNAs wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ditzler, Mark A., Lange, Margaret J., Bose, Debojit, Bottoms, Christopher A., Virkler, Katherine F., Sawyer, Andrew W., Whatley, Angela S., Spollen, William, Givan, Scott A., Burke, Donald H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561961/ https://www.ncbi.nlm.nih.gov/pubmed/23241386 http://dx.doi.org/10.1093/nar/gks1190

Ejemplares similares

Potent Inhibition of HIV-1 Reverse Transcriptase and Replication by Nonpseudoknot, “UCAA-motif” RNA Aptamers
por: Whatley, Angela S, et al.
Publicado: (2013)

RNA–protein interactions govern antiviral specificity and encapsidation of broad spectrum anti-HIV reverse transcriptase aptamers
por: Lange, Margaret J., et al.
Publicado: (2017)

Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates
por: Ditzler, Mark A., et al.
Publicado: (2011)

Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase
por: Nguyen, Phuong D M, et al.
Publicado: (2020)

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase
por: Li, Na, et al.
Publicado: (2008)

Trans-lesion synthesis and RNaseH activity by reverse transcriptases on a true abasic RNA template
por: Küpfer, Pascal A., et al.
Publicado: (2007)

In vitro evolution of distinct self-cleaving ribozymes in diverse environments
por: Popović, Milena, et al.
Publicado: (2015)

Synthesis, base pairing properties and trans-lesion synthesis by reverse transcriptases of oligoribonucleotides containing the oxidatively damaged base 5-hydroxycytidine
por: Küpfer, Pascal A., et al.
Publicado: (2011)

Post-transcriptional modification mapping in the Clostridium acetobutylicum 16S rRNA by mass spectrometry and reverse transcriptase assays
por: Emmerechts, Gert, et al.
Publicado: (2007)

Human telomerase reverse transcriptase binds to a pre-organized hTR in vivo exposing its template
por: Zemora, Georgeta, et al.
Publicado: (2016)

Retron reverse transcriptase termination and phage defense are dependent on host RNase H1
por: Palka, Christina, et al.
Publicado: (2022)

Non-templated addition and template switching by Moloney murine leukemia virus (MMLV)-based reverse transcriptases co-occur and compete with each other
por: Wulf, Madalee G., et al.
Publicado: (2019)

A rugged free energy landscape separates multiple functional RNA folds throughout denaturation
por: Ditzler, Mark A., et al.
Publicado: (2008)

Competition for RISC binding predicts in vitro potency of siRNA
por: Koller, Erich, et al.
Publicado: (2006)

Modified dsRNAs that are not processed by Dicer maintain potency and are incorporated into the RISC
por: Salomon, William, et al.
Publicado: (2010)

The extent of sequence complementarity correlates with the potency of cellular miRNA-mediated restriction of HIV-1
por: Houzet, Laurent, et al.
Publicado: (2012)

Strand antagonism in RNAi: an explanation of differences in potency between intracellularly expressed siRNA and shRNA
por: Jin, Xin, et al.
Publicado: (2012)

Functional annotation of lncRNA in high-throughput screening
por: Yip, Chi Wai, et al.
Publicado: (2021)

Selection and identification of an RNA aptamer that specifically binds the HIV-1 capsid lattice and inhibits viral replication
por: Gruenke, Paige R, et al.
Publicado: (2022)

High-throughput single-base resolution mapping of RNA 2΄-O-methylated residues
por: Incarnato, Danny, et al.
Publicado: (2017)

A small ribozyme with dual-site kinase activity
por: Biondi, Elisa, et al.
Publicado: (2012)

Identifying transcriptional start sites of human microRNAs based on high-throughput sequencing data
por: Chien, Chia-Hung, et al.
Publicado: (2011)

Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines
por: Tosar, Juan Pablo, et al.
Publicado: (2015)

Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants
por: Frey, Kathleen M., et al.
Publicado: (2015)

Virion packaging determinants and reverse transcription of SRP RNA in HIV-1 particles
por: Tian, Chunjuan, et al.
Publicado: (2007)

The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent
por: Hauenschild, Ralf, et al.
Publicado: (2015)

High-throughput identification of RNA localization elements in neuronal cells
por: Arora, Ankita, et al.
Publicado: (2022)

Assessing the gene regulatory properties of Argonaute-bound small RNAs of diverse genomic origin
por: Thomson, Daniel W., et al.
Publicado: (2015)

The availability of the primer activation signal (PAS) affects the efficiency of HIV-1 reverse transcription initiation
por: Ooms, Marcel, et al.
Publicado: (2007)

The RNA ligase RtcB reverses MazF-induced ribosome heterogeneity in Escherichia coli
por: Temmel, Hannes, et al.
Publicado: (2017)

Vif is a RNA chaperone that could temporally regulate RNA dimerization and the early steps of HIV-1 reverse transcription
por: Henriet, S., et al.
Publicado: (2007)

Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases
por: Michalowski, Daniel, et al.
Publicado: (2008)

miR-137 targets the inhibition of TCF4 to reverse the progression of osteoarthritis through the AMPK/NF-κB signaling pathway
por: Wang, Jinyu, et al.
Publicado: (2020)

Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase
por: Ndongwe, Tanyaradzwa P., et al.
Publicado: (2012)

A diversity of uncharacterized reverse transcriptases in bacteria
por: Simon, Dawn M., et al.
Publicado: (2008)

A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex
por: Rodgers, Margaret L., et al.
Publicado: (2016)

Identification of tri-phosphatase activity in the biogenesis of retroviral microRNAs and RNAP III-generated shRNAs
por: Burke, James M., et al.
Publicado: (2014)

An RRM–ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion
por: Collins, Katherine M., et al.
Publicado: (2017)

A high-throughput screen identifies small molecule modulators of alternative splicing by targeting RNA G-quadruplexes
por: Zhang, Jing, et al.
Publicado: (2019)

Diverse regulatory manners of human telomerase reverse transcriptase
por: Jie, Meng-Meng, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8nlln7e8mbh8hoi0lgge18r3oh