Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction

Classic non-homologous end joining (C-NHEJ) is the predominant DNA double-strand break repair pathway in humans. Although seven genes Ku70, Ku86, DNA-PK(cs), Artemis, DNA Ligase IV (LIGIV), X-ray cross-complementing group 4 and XRCC4-like factor are required for C-NHEJ, several of them also have anc...

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Detalles Bibliográficos
Autores principales: Oh, Sehyun, Wang, Yongbao, Zimbric, Jacob, Hendrickson, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561972/
https://www.ncbi.nlm.nih.gov/pubmed/23275564
http://dx.doi.org/10.1093/nar/gks1326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561972/
https://www.ncbi.nlm.nih.gov/pubmed/23275564
http://dx.doi.org/10.1093/nar/gks1326

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