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DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion

A major base lesion resulting from oxidative stress is 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxoG) that has ambiguous coding potential. Error-free DNA synthesis involves 8-oxoG adopting an anti-conformation to base pair with cytosine whereas mutagenic bypass involves 8-oxoG adopting a syn-conformat...

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Detalles Bibliográficos
Autores principales:	Freudenthal, Bret D., Beard, William A., Wilson, Samuel H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561998/ https://www.ncbi.nlm.nih.gov/pubmed/23267011 http://dx.doi.org/10.1093/nar/gks1276

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