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Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP

Motivation: TRAIL has been widely studied for the ability to kill cancer cells selectively, but its clinical usefulness has been hindered by the development of resistance. Multiple compounds have been identified that sensitize cancer cells to TRAIL-induced apoptosis. The drug LY303511 (LY30), combin...

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Detalles Bibliográficos
Autores principales:	Shi, Yuan, Mellier, Gregory, Huang, Sinong, White, Jacob, Pervaiz, Shazib, Tucker-Kellogg, Lisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562069/ https://www.ncbi.nlm.nih.gov/pubmed/23239672 http://dx.doi.org/10.1093/bioinformatics/bts702

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