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11β-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates Atherosclerosis and In Vivo Foam Cell Formation in Hyperlipidemic apoE(−/−) Mice

BACKGROUND: Chronic glucocorticoid excess has been linked to increased atherosclerosis and general cardiovascular risk in humans. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) increases active glucocorticoid levels within tissues by catalyzing the conversion of cortisone to cortisol....

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Detalles Bibliográficos
Autores principales:	García, Ricardo A., Search, Debra J., Lupisella, John A., Ostrowski, Jacek, Guan, Bo, Chen, Jian, Yang, Wen-Pin, Truong, Amy, He, Aiqing, Zhang, Rongan, Yan, Mujing, Hellings, Samuel E., Gargalovic, Peter S., Ryan, Carol S., Watson, Linda M., Langish, Robert A., Shipkova, Petia A., Carson, Nancy L., Taylor, Joseph R., Yang, Richard, Psaltis, George C., Harrity, Thomas W., Robl, Jeffrey A., Gordon, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562192/ https://www.ncbi.nlm.nih.gov/pubmed/23383297 http://dx.doi.org/10.1371/journal.pone.0053192

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