Rad9, Rad17, TopBP1 and Claspin Play Essential Roles in Heat-Induced Activation of ATR Kinase and Heat Tolerance

Hyperthermia is widely used to treat patients with cancer, especially in combination with other treatments such as radiation therapy. Heat treatment per se activates DNA damage responses mediated by the ATR-Chk1 and ATM-Chk2 pathways but it is not fully understood how these DNA damage responses are...

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Detalles Bibliográficos
Autores principales: Tuul, Munkhbold, Kitao, Hiroyuki, Iimori, Makoto, Matsuoka, Kazuaki, Kiyonari, Shinichi, Saeki, Hiroshi, Oki, Eiji, Morita, Masaru, Maehara, Yoshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562228/
https://www.ncbi.nlm.nih.gov/pubmed/23383325
http://dx.doi.org/10.1371/journal.pone.0055361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562228/
https://www.ncbi.nlm.nih.gov/pubmed/23383325
http://dx.doi.org/10.1371/journal.pone.0055361

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