Inhibitors of the Influenza A Virus M2 Proton Channel Discovered Using a High-Throughput Yeast Growth Restoration Assay

The M2 proton channel of the influenza A virus is the target of the anti-influenza drugs amantadine and rimantadine. The effectiveness of these drugs has been dramatically limited by the rapid spread of drug resistant mutations, mainly at sites S31N, V27A and L26F in the pore of the channel. Despite...

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Detalles Bibliográficos
Autores principales: Balgi, Aruna D., Wang, Jun, Cheng, Daphne Y. H., Ma, Chunlong, Pfeifer, Tom A., Shimizu, Yoko, Anderson, Hilary J., Pinto, Lawrence H., Lamb, Robert A., DeGrado, William F., Roberge, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562233/
https://www.ncbi.nlm.nih.gov/pubmed/23383318
http://dx.doi.org/10.1371/journal.pone.0055271

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