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A new mechanism of action of sulodexide in diabetic nephropathy: inhibits heparanase-1 and prevents FGF-2-induced renal epithelial-mesenchymal transition

BACKGROUND: Epithelial-mesenchymal transition of tubular cells is a widely recognized mechanism that sustains interstitial fibrosis in diabetic nephropathy (DN). The signaling of FGF-2, a growth factor involved in this mechanism, is regulated by glycosaminoglycans. Heparanase-1, an endoglycosidase t...

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Detalles Bibliográficos
Autores principales:	Masola, Valentina, Onisto, Maurizio, Zaza, Gianluigi, Lupo, Antonio, Gambaro, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562257/ https://www.ncbi.nlm.nih.gov/pubmed/23095131 http://dx.doi.org/10.1186/1479-5876-10-213

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