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Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells

FK866 is a specific inhibitor of NAMPT and induces apoptosis of leukemic cells by depletion of intracellular NAD(+). Since up-regulation of NAMPT is associated with several cases of cancers, including leukemias, we asked whether in leukemic cells inhibition of NAMPT involves p53 pathway. We observed...

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Detalles Bibliográficos
Autores principales:	Thakur, Basant Kumar, Dittrich, Tino, Chandra, Prakash, Becker, Annette, Kuehnau, Wolfgang, Klusmann, Jan-Henning, Reinhardt, Dirk, Welte, Karl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley Subscription Services, Inc., A Wiley Company 2013
Materias:	Carcinogenesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562481/ https://www.ncbi.nlm.nih.gov/pubmed/22815158 http://dx.doi.org/10.1002/ijc.27726

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