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IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications

Since the discovery of IL-17 in 1995 as a T-cell cytokine, inducing IL-6 and IL-8 production by fibroblasts, and the report of a separate T-cell lineage producing IL-17(A), called Th17 cells, in 2005, the role of IL-17 has been studied in several inflammatory diseases. By inducing IL-8 production an...

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Autores principales: Bullens, Dominique M. A., Decraene, Ann, Seys, Sven, Dupont, Lieven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562607/
https://www.ncbi.nlm.nih.gov/pubmed/23401702
http://dx.doi.org/10.1155/2013/840315
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author Bullens, Dominique M. A.
Decraene, Ann
Seys, Sven
Dupont, Lieven J.
author_facet Bullens, Dominique M. A.
Decraene, Ann
Seys, Sven
Dupont, Lieven J.
author_sort Bullens, Dominique M. A.
collection PubMed
description Since the discovery of IL-17 in 1995 as a T-cell cytokine, inducing IL-6 and IL-8 production by fibroblasts, and the report of a separate T-cell lineage producing IL-17(A), called Th17 cells, in 2005, the role of IL-17 has been studied in several inflammatory diseases. By inducing IL-8 production and subsequent neutrophil attraction towards the site of inflammation, IL-17A can link adaptive and innate immune responses. More specifically, its role in respiratory diseases has intensively been investigated. We here review its role in human respiratory diseases and try to unravel the question whether IL-17A only provides a link between the adaptive and innate respiratory immunity or whether this cytokine might also be locally produced by innate immune cells. We furthermore briefly discuss the possibility to reduce local IL-17A production as a treatment option for respiratory diseases.
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spelling pubmed-35626072013-02-11 IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications Bullens, Dominique M. A. Decraene, Ann Seys, Sven Dupont, Lieven J. Clin Dev Immunol Review Article Since the discovery of IL-17 in 1995 as a T-cell cytokine, inducing IL-6 and IL-8 production by fibroblasts, and the report of a separate T-cell lineage producing IL-17(A), called Th17 cells, in 2005, the role of IL-17 has been studied in several inflammatory diseases. By inducing IL-8 production and subsequent neutrophil attraction towards the site of inflammation, IL-17A can link adaptive and innate immune responses. More specifically, its role in respiratory diseases has intensively been investigated. We here review its role in human respiratory diseases and try to unravel the question whether IL-17A only provides a link between the adaptive and innate respiratory immunity or whether this cytokine might also be locally produced by innate immune cells. We furthermore briefly discuss the possibility to reduce local IL-17A production as a treatment option for respiratory diseases. Hindawi Publishing Corporation 2013 2013-01-17 /pmc/articles/PMC3562607/ /pubmed/23401702 http://dx.doi.org/10.1155/2013/840315 Text en Copyright © 2013 Dominique M. A. Bullens et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bullens, Dominique M. A.
Decraene, Ann
Seys, Sven
Dupont, Lieven J.
IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications
title IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications
title_full IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications
title_fullStr IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications
title_full_unstemmed IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications
title_short IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications
title_sort il-17a in human respiratory diseases: innate or adaptive immunity? clinical implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562607/
https://www.ncbi.nlm.nih.gov/pubmed/23401702
http://dx.doi.org/10.1155/2013/840315
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