Cargando…
IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications
Since the discovery of IL-17 in 1995 as a T-cell cytokine, inducing IL-6 and IL-8 production by fibroblasts, and the report of a separate T-cell lineage producing IL-17(A), called Th17 cells, in 2005, the role of IL-17 has been studied in several inflammatory diseases. By inducing IL-8 production an...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562607/ https://www.ncbi.nlm.nih.gov/pubmed/23401702 http://dx.doi.org/10.1155/2013/840315 |
_version_ | 1782258113413382144 |
---|---|
author | Bullens, Dominique M. A. Decraene, Ann Seys, Sven Dupont, Lieven J. |
author_facet | Bullens, Dominique M. A. Decraene, Ann Seys, Sven Dupont, Lieven J. |
author_sort | Bullens, Dominique M. A. |
collection | PubMed |
description | Since the discovery of IL-17 in 1995 as a T-cell cytokine, inducing IL-6 and IL-8 production by fibroblasts, and the report of a separate T-cell lineage producing IL-17(A), called Th17 cells, in 2005, the role of IL-17 has been studied in several inflammatory diseases. By inducing IL-8 production and subsequent neutrophil attraction towards the site of inflammation, IL-17A can link adaptive and innate immune responses. More specifically, its role in respiratory diseases has intensively been investigated. We here review its role in human respiratory diseases and try to unravel the question whether IL-17A only provides a link between the adaptive and innate respiratory immunity or whether this cytokine might also be locally produced by innate immune cells. We furthermore briefly discuss the possibility to reduce local IL-17A production as a treatment option for respiratory diseases. |
format | Online Article Text |
id | pubmed-3562607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35626072013-02-11 IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications Bullens, Dominique M. A. Decraene, Ann Seys, Sven Dupont, Lieven J. Clin Dev Immunol Review Article Since the discovery of IL-17 in 1995 as a T-cell cytokine, inducing IL-6 and IL-8 production by fibroblasts, and the report of a separate T-cell lineage producing IL-17(A), called Th17 cells, in 2005, the role of IL-17 has been studied in several inflammatory diseases. By inducing IL-8 production and subsequent neutrophil attraction towards the site of inflammation, IL-17A can link adaptive and innate immune responses. More specifically, its role in respiratory diseases has intensively been investigated. We here review its role in human respiratory diseases and try to unravel the question whether IL-17A only provides a link between the adaptive and innate respiratory immunity or whether this cytokine might also be locally produced by innate immune cells. We furthermore briefly discuss the possibility to reduce local IL-17A production as a treatment option for respiratory diseases. Hindawi Publishing Corporation 2013 2013-01-17 /pmc/articles/PMC3562607/ /pubmed/23401702 http://dx.doi.org/10.1155/2013/840315 Text en Copyright © 2013 Dominique M. A. Bullens et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bullens, Dominique M. A. Decraene, Ann Seys, Sven Dupont, Lieven J. IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications |
title | IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications |
title_full | IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications |
title_fullStr | IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications |
title_full_unstemmed | IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications |
title_short | IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications |
title_sort | il-17a in human respiratory diseases: innate or adaptive immunity? clinical implications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562607/ https://www.ncbi.nlm.nih.gov/pubmed/23401702 http://dx.doi.org/10.1155/2013/840315 |
work_keys_str_mv | AT bullensdominiquema il17ainhumanrespiratorydiseasesinnateoradaptiveimmunityclinicalimplications AT decraeneann il17ainhumanrespiratorydiseasesinnateoradaptiveimmunityclinicalimplications AT seyssven il17ainhumanrespiratorydiseasesinnateoradaptiveimmunityclinicalimplications AT dupontlievenj il17ainhumanrespiratorydiseasesinnateoradaptiveimmunityclinicalimplications |