Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines

We reviewed the phenotypic and molecular characteristics of MCF10DCIS.com and the SUM cell lines based on numerous studies performed over the years. The major signaling pathways that give rise to the phenotype of these cells may serve as a good resource of information when researchers in drug discov...

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Detalles Bibliográficos
Autores principales: Barnabas, Nandita, Cohen, Dalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562669/
https://www.ncbi.nlm.nih.gov/pubmed/23401782
http://dx.doi.org/10.1155/2013/872743
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author Barnabas, Nandita
Cohen, Dalia
author_facet Barnabas, Nandita
Cohen, Dalia
author_sort Barnabas, Nandita
collection PubMed
description We reviewed the phenotypic and molecular characteristics of MCF10DCIS.com and the SUM cell lines based on numerous studies performed over the years. The major signaling pathways that give rise to the phenotype of these cells may serve as a good resource of information when researchers in drug discovery and development use these cells to identify novel targets and biomarkers. Major signaling pathways and mutations affecting the coding sequence are also described providing important information when using these cells as a model in a variety of studies.
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spelling pubmed-35626692013-02-11 Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines Barnabas, Nandita Cohen, Dalia Int J Breast Cancer Review Article We reviewed the phenotypic and molecular characteristics of MCF10DCIS.com and the SUM cell lines based on numerous studies performed over the years. The major signaling pathways that give rise to the phenotype of these cells may serve as a good resource of information when researchers in drug discovery and development use these cells to identify novel targets and biomarkers. Major signaling pathways and mutations affecting the coding sequence are also described providing important information when using these cells as a model in a variety of studies. Hindawi Publishing Corporation 2013 2013-01-16 /pmc/articles/PMC3562669/ /pubmed/23401782 http://dx.doi.org/10.1155/2013/872743 Text en Copyright © 2013 N. Barnabas and D. Cohen. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Barnabas, Nandita
Cohen, Dalia
Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines
title Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines
title_full Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines
title_fullStr Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines
title_full_unstemmed Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines
title_short Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines
title_sort phenotypic and molecular characterization of mcf10dcis and sum breast cancer cell lines
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562669/
https://www.ncbi.nlm.nih.gov/pubmed/23401782
http://dx.doi.org/10.1155/2013/872743
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