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Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective
The increasing burden of major depressive disorder makes the search for an extended understanding of etiology, and for the development of additional treatments highly significant. Biological factors may be useful biomarkers for treatment with physical activity (PA), and neurobiological effects of PA...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562851/ https://www.ncbi.nlm.nih.gov/pubmed/23382717 http://dx.doi.org/10.3389/fpsyt.2013.00003 |
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author | Eyre, Harris A. Papps, Evan Baune, Bernhard T. |
author_facet | Eyre, Harris A. Papps, Evan Baune, Bernhard T. |
author_sort | Eyre, Harris A. |
collection | PubMed |
description | The increasing burden of major depressive disorder makes the search for an extended understanding of etiology, and for the development of additional treatments highly significant. Biological factors may be useful biomarkers for treatment with physical activity (PA), and neurobiological effects of PA may herald new therapeutic development in the future. This paper provides a thorough and up-to-date review of studies examining the neuroimmunomodulatory effects of PA on the brain in depression and depression-like behaviors. From a neuroimmune perspective, evidence suggests PA does enhance the beneficial and reduce the detrimental effects of the neuroimmune system. PA appears to increase the following factors: interleukin (IL)-10, IL-6 (acutely), macrophage migration inhibitory factor, central nervous system-specific autoreactive CD4+ T cells, M2 microglia, quiescent astrocytes, CX3CL1, and insulin-like growth factor-1. On the other hand, PA appears to reduce detrimental neuroimmune factors such as: Th1/Th2 balance, pro-inflammatory cytokines, C-reactive protein, M1 microglia, and reactive astrocytes. The effect of other mechanisms is unknown, such as: CD4+CD25+ T regulatory cells (T regs), CD200, chemokines, miRNA, M2-type blood-derived macrophages, and tumor necrosis factor (TNF)-α [via receptor 2 (R2)]. The beneficial effects of PA are likely to occur centrally and peripherally (e.g., in visceral fat reduction). The investigation of the neuroimmune effects of PA on depression and depression-like behavior is a rapidly developing and important field. |
format | Online Article Text |
id | pubmed-3562851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35628512013-02-04 Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective Eyre, Harris A. Papps, Evan Baune, Bernhard T. Front Psychiatry Psychiatry The increasing burden of major depressive disorder makes the search for an extended understanding of etiology, and for the development of additional treatments highly significant. Biological factors may be useful biomarkers for treatment with physical activity (PA), and neurobiological effects of PA may herald new therapeutic development in the future. This paper provides a thorough and up-to-date review of studies examining the neuroimmunomodulatory effects of PA on the brain in depression and depression-like behaviors. From a neuroimmune perspective, evidence suggests PA does enhance the beneficial and reduce the detrimental effects of the neuroimmune system. PA appears to increase the following factors: interleukin (IL)-10, IL-6 (acutely), macrophage migration inhibitory factor, central nervous system-specific autoreactive CD4+ T cells, M2 microglia, quiescent astrocytes, CX3CL1, and insulin-like growth factor-1. On the other hand, PA appears to reduce detrimental neuroimmune factors such as: Th1/Th2 balance, pro-inflammatory cytokines, C-reactive protein, M1 microglia, and reactive astrocytes. The effect of other mechanisms is unknown, such as: CD4+CD25+ T regulatory cells (T regs), CD200, chemokines, miRNA, M2-type blood-derived macrophages, and tumor necrosis factor (TNF)-α [via receptor 2 (R2)]. The beneficial effects of PA are likely to occur centrally and peripherally (e.g., in visceral fat reduction). The investigation of the neuroimmune effects of PA on depression and depression-like behavior is a rapidly developing and important field. Frontiers Media S.A. 2013-02-04 /pmc/articles/PMC3562851/ /pubmed/23382717 http://dx.doi.org/10.3389/fpsyt.2013.00003 Text en Copyright © 2013 Eyre, Papps and Baune. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Psychiatry Eyre, Harris A. Papps, Evan Baune, Bernhard T. Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective |
title | Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective |
title_full | Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective |
title_fullStr | Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective |
title_full_unstemmed | Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective |
title_short | Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective |
title_sort | treating depression and depression-like behavior with physical activity: an immune perspective |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562851/ https://www.ncbi.nlm.nih.gov/pubmed/23382717 http://dx.doi.org/10.3389/fpsyt.2013.00003 |
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