COX-2 in the neurodegenerative process of Parkinson's disease

The enzyme cyclooxygenase-2 (COX-2), responsible for the first committed step in the synthesis of several important mediators which are involved in both initiation and resolution of inflammation, and the subsequent generation of prostaglandins (PGs) upon activation has been shown to participate in t...

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Detalles Bibliográficos
Autor principal: Teismann, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563218/
https://www.ncbi.nlm.nih.gov/pubmed/22826171
http://dx.doi.org/10.1002/biof.1035
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author Teismann, Peter
author_facet Teismann, Peter
author_sort Teismann, Peter
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description The enzyme cyclooxygenase-2 (COX-2), responsible for the first committed step in the synthesis of several important mediators which are involved in both initiation and resolution of inflammation, and the subsequent generation of prostaglandins (PGs) upon activation has been shown to participate in the neurodegenerative processes of a variety of diseases. This review looks particular at the role of COX-2 in the pathogenesis of Parkinson's disease, involving the generation of PGs and the role of the two different parts of the cyclooxygenase—cyclooxygenase and peroxidase activity.
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spelling pubmed-35632182013-02-07 COX-2 in the neurodegenerative process of Parkinson's disease Teismann, Peter Biofactors Review Articles The enzyme cyclooxygenase-2 (COX-2), responsible for the first committed step in the synthesis of several important mediators which are involved in both initiation and resolution of inflammation, and the subsequent generation of prostaglandins (PGs) upon activation has been shown to participate in the neurodegenerative processes of a variety of diseases. This review looks particular at the role of COX-2 in the pathogenesis of Parkinson's disease, involving the generation of PGs and the role of the two different parts of the cyclooxygenase—cyclooxygenase and peroxidase activity. Wiley Subscription Services, Inc., A Wiley Company 2012-11 2012-07-23 /pmc/articles/PMC3563218/ /pubmed/22826171 http://dx.doi.org/10.1002/biof.1035 Text en Copyright © 2012 International Union of Biochemistry and Molecular Biology, Inc. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Review Articles
Teismann, Peter
COX-2 in the neurodegenerative process of Parkinson's disease
title COX-2 in the neurodegenerative process of Parkinson's disease
title_full COX-2 in the neurodegenerative process of Parkinson's disease
title_fullStr COX-2 in the neurodegenerative process of Parkinson's disease
title_full_unstemmed COX-2 in the neurodegenerative process of Parkinson's disease
title_short COX-2 in the neurodegenerative process of Parkinson's disease
title_sort cox-2 in the neurodegenerative process of parkinson's disease
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563218/
https://www.ncbi.nlm.nih.gov/pubmed/22826171
http://dx.doi.org/10.1002/biof.1035
work_keys_str_mv AT teismannpeter cox2intheneurodegenerativeprocessofparkinsonsdisease

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