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Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study
BACKGROUND: Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. OBJECTIVE: To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany. PATIENTS AND METHODS: The research reported here was a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563346/ https://www.ncbi.nlm.nih.gov/pubmed/23386790 http://dx.doi.org/10.2147/IDR.S38945 |
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author | Wissing, Heimo Ballus, Jose Bingold, Tobias M Nocea, Gonzalo Krobot, Karl J Kaskel, Peter Kumar, Ritesh N Mavros, Panagiotis |
author_facet | Wissing, Heimo Ballus, Jose Bingold, Tobias M Nocea, Gonzalo Krobot, Karl J Kaskel, Peter Kumar, Ritesh N Mavros, Panagiotis |
author_sort | Wissing, Heimo |
collection | PubMed |
description | BACKGROUND: Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. OBJECTIVE: To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany. PATIENTS AND METHODS: The research reported here was a prospective multicenter longitudinal observational study in adult intensive care unit patients receiving IV fluconazole. Demographic, microbiologic, therapy success, length of hospital stay, adverse event, and all-cause mortality data were collected at 14 sites in Spain and five in Germany, from February 2004 to November 2005. RESULTS: Patients (n = 303) received prophylaxis (n = 29), empiric therapy (n = 140), preemptive therapy (n = 85), or definitive therapy (n = 49). A total of 298 patients (98.4%) were treated with IV fluconazole as first-line therapy. The treating physicians judged therapy successful in 66% of prophylactic, 55% of empiric, 45% of preemptive, and 43% of definitive group patients. In the subgroup of 152 patients with proven and specified Candida infection only, 32% suffered from Candida specified as potentially resistant to IV fluconazole. The overall mortality rate was 42%. CONCLUSION: Our study informs treatment decision makers that approximately 32% of the patients with microbiological results available suffered from Candida specified as potentially resistant to IV fluconazole, highlighting the importance of appropriate therapy. |
format | Online Article Text |
id | pubmed-3563346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-35633462013-02-05 Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study Wissing, Heimo Ballus, Jose Bingold, Tobias M Nocea, Gonzalo Krobot, Karl J Kaskel, Peter Kumar, Ritesh N Mavros, Panagiotis Infect Drug Resist Original Research BACKGROUND: Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. OBJECTIVE: To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany. PATIENTS AND METHODS: The research reported here was a prospective multicenter longitudinal observational study in adult intensive care unit patients receiving IV fluconazole. Demographic, microbiologic, therapy success, length of hospital stay, adverse event, and all-cause mortality data were collected at 14 sites in Spain and five in Germany, from February 2004 to November 2005. RESULTS: Patients (n = 303) received prophylaxis (n = 29), empiric therapy (n = 140), preemptive therapy (n = 85), or definitive therapy (n = 49). A total of 298 patients (98.4%) were treated with IV fluconazole as first-line therapy. The treating physicians judged therapy successful in 66% of prophylactic, 55% of empiric, 45% of preemptive, and 43% of definitive group patients. In the subgroup of 152 patients with proven and specified Candida infection only, 32% suffered from Candida specified as potentially resistant to IV fluconazole. The overall mortality rate was 42%. CONCLUSION: Our study informs treatment decision makers that approximately 32% of the patients with microbiological results available suffered from Candida specified as potentially resistant to IV fluconazole, highlighting the importance of appropriate therapy. Dove Medical Press 2013-01-30 /pmc/articles/PMC3563346/ /pubmed/23386790 http://dx.doi.org/10.2147/IDR.S38945 Text en © 2013 Wissing et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Wissing, Heimo Ballus, Jose Bingold, Tobias M Nocea, Gonzalo Krobot, Karl J Kaskel, Peter Kumar, Ritesh N Mavros, Panagiotis Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study |
title | Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study |
title_full | Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study |
title_fullStr | Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study |
title_full_unstemmed | Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study |
title_short | Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study |
title_sort | intensive care unit-related fluconazole use in spain and germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563346/ https://www.ncbi.nlm.nih.gov/pubmed/23386790 http://dx.doi.org/10.2147/IDR.S38945 |
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