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Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample
BACKGROUND: Insulin-like growth factor I (IGF-I), which is mostly carried in blood by IGF-binding protein 3 (IGFBP-3), was associated to the glomerular filtration rate and chronic kidney disease in a multiethnic study among US adults. The aim of the present study was to investigate whether serum IGF...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563443/ https://www.ncbi.nlm.nih.gov/pubmed/23237568 http://dx.doi.org/10.1186/1471-2369-13-169 |
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author | Dittmann, Kathleen Wallaschofski, Henri Rettig, Rainer Stracke, Sylvia Endlich, Karlhans Völzke, Henry Nauck, Matthias Friedrich, Nele |
author_facet | Dittmann, Kathleen Wallaschofski, Henri Rettig, Rainer Stracke, Sylvia Endlich, Karlhans Völzke, Henry Nauck, Matthias Friedrich, Nele |
author_sort | Dittmann, Kathleen |
collection | PubMed |
description | BACKGROUND: Insulin-like growth factor I (IGF-I), which is mostly carried in blood by IGF-binding protein 3 (IGFBP-3), was associated to the glomerular filtration rate and chronic kidney disease in a multiethnic study among US adults. The aim of the present study was to investigate whether serum IGF-I or IGFBP-3 are associated with estimated glomerular filtration rate (eGFR) in a population-based study of Caucasian adults. METHODS: Data from 4028 subjects (2048 women) aged 20 to 81 years from the Study of Health in Pomerania (SHIP) were analyzed. Total serum IGF-I and IGFBP-3 concentrations were determined by chemiluminescence immunoassays and categorized into sex- and age-specific quartiles. RESULTS: After adjusting for age, waist circumference and type 2 diabetes mellitus, analysis of variance (ANOVA) revealed inverse associations between serum IGF-I concentrations and eGFR in men as well as between serum IGFBP-3 concentrations and eGFR in men and women. Logistic regression analyses confirmed these findings and showed that high IGF-I or IGFBP-3 concentrations were associated with an increased risk of decreased eGFR (<60 mL/min/1.73 m(2)) in men or women. These relations became stronger when lower eGFR cut-offs were used for the analyses. CONCLUSION: Our data revealed associations of increased serum IGF-I concentrations and decreased eGFR in men but not in women and an association of increased serum IGFBP-3 concentrations and decreased eGFR in both sexes. |
format | Online Article Text |
id | pubmed-3563443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35634432013-02-08 Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample Dittmann, Kathleen Wallaschofski, Henri Rettig, Rainer Stracke, Sylvia Endlich, Karlhans Völzke, Henry Nauck, Matthias Friedrich, Nele BMC Nephrol Research Article BACKGROUND: Insulin-like growth factor I (IGF-I), which is mostly carried in blood by IGF-binding protein 3 (IGFBP-3), was associated to the glomerular filtration rate and chronic kidney disease in a multiethnic study among US adults. The aim of the present study was to investigate whether serum IGF-I or IGFBP-3 are associated with estimated glomerular filtration rate (eGFR) in a population-based study of Caucasian adults. METHODS: Data from 4028 subjects (2048 women) aged 20 to 81 years from the Study of Health in Pomerania (SHIP) were analyzed. Total serum IGF-I and IGFBP-3 concentrations were determined by chemiluminescence immunoassays and categorized into sex- and age-specific quartiles. RESULTS: After adjusting for age, waist circumference and type 2 diabetes mellitus, analysis of variance (ANOVA) revealed inverse associations between serum IGF-I concentrations and eGFR in men as well as between serum IGFBP-3 concentrations and eGFR in men and women. Logistic regression analyses confirmed these findings and showed that high IGF-I or IGFBP-3 concentrations were associated with an increased risk of decreased eGFR (<60 mL/min/1.73 m(2)) in men or women. These relations became stronger when lower eGFR cut-offs were used for the analyses. CONCLUSION: Our data revealed associations of increased serum IGF-I concentrations and decreased eGFR in men but not in women and an association of increased serum IGFBP-3 concentrations and decreased eGFR in both sexes. BioMed Central 2012-12-13 /pmc/articles/PMC3563443/ /pubmed/23237568 http://dx.doi.org/10.1186/1471-2369-13-169 Text en Copyright ©2012 Dittmann et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Dittmann, Kathleen Wallaschofski, Henri Rettig, Rainer Stracke, Sylvia Endlich, Karlhans Völzke, Henry Nauck, Matthias Friedrich, Nele Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample |
title | Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample |
title_full | Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample |
title_fullStr | Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample |
title_full_unstemmed | Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample |
title_short | Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample |
title_sort | association between serum insulin-like growth factor i or igf-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563443/ https://www.ncbi.nlm.nih.gov/pubmed/23237568 http://dx.doi.org/10.1186/1471-2369-13-169 |
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