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Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions
BACKGROUND: Cancer, much like most human disease, is routinely studied by utilizing model organisms. Of these model organisms, mice are often dominant. However, our assumptions of functional equivalence fail to consider the opportunity for divergence conferred by ~180 Million Years (MY) of independe...
Autores principales: | Morgan, Claire C, Shakya, Kabita, Webb, Andrew, Walsh, Thomas A, Lynch, Mark, Loscher, Christine E, Ruskin, Heather J, O’Connell, Mary J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563467/ https://www.ncbi.nlm.nih.gov/pubmed/22788692 http://dx.doi.org/10.1186/1471-2148-12-114 |
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