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Changes in Timing and kinematics of goal directed eye-hand movements in early-stage Parkinson’s disease

OBJECTIVE: Many daily activities involve intrinsic or extrinsic goal-directed eye and hand movements. An extensive visuomotor coordination network including nigro-striatal pathways is required for efficient timing and positioning of eyes and hands. The aim of this study was to investigate how Parkin...

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Autores principales: Muilwijk, Danya, Verheij, Simone, Pel, Johan JM, Boon, Agnita JW, van der Steen, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563471/
https://www.ncbi.nlm.nih.gov/pubmed/23298720
http://dx.doi.org/10.1186/2047-9158-2-1
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author Muilwijk, Danya
Verheij, Simone
Pel, Johan JM
Boon, Agnita JW
van der Steen, Johannes
author_facet Muilwijk, Danya
Verheij, Simone
Pel, Johan JM
Boon, Agnita JW
van der Steen, Johannes
author_sort Muilwijk, Danya
collection PubMed
description OBJECTIVE: Many daily activities involve intrinsic or extrinsic goal-directed eye and hand movements. An extensive visuomotor coordination network including nigro-striatal pathways is required for efficient timing and positioning of eyes and hands. The aim of this study was to investigate how Parkinson’s disease (PD) affects eye-hand coordination in tasks with different cognitive complexity. METHODS: We used a touch screen, an eye-tracking device and a motion capturing system to quantify changes in eye-hand coordination in early-stage PD patients (H&Y < 2.5) and age-matched controls. Timing and kinematics of eye and hand were quantified in four eye-hand coordination tasks (pro-tapping, dual planning, anti-tapping and spatial memory task). RESULTS: In the pro-tapping task, saccade initiation towards extrinsic goals was not impaired. However, in the dual planning and anti-tapping task initiation of saccades towards intrinsic goals was faster in PD patients. Hand movements were differently affected: initiation of the hand movement was only delayed in the pro-tapping and dual planning task. Overall, hand movements in PD patients were slower executed compared to controls. INTERPRETATION: Whereas initiation of saccades in an extrinsic goal-directed task (pro-tapping task) is not affected, early stage PD patients have difficulty in suppressing reflexive saccades towards extrinsic goals in tasks where the endpoint is an intrinsic goal (e.g. dual planning and anti-tapping task). This is specific for eye movements, as hand movements have delayed responses in the pro-tapping and dual planning task. This suggests that reported impairment of the dorsolateral prefrontal cortex in early-stage PD patients affects only inhibition of eye movements. We conclude that timing and kinematics of eye and hand movements in visuomotor tasks are affected in PD patients. This result may have clinical significance by providing a behavioral marker for the early diagnosis of PD.
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spelling pubmed-35634712013-02-08 Changes in Timing and kinematics of goal directed eye-hand movements in early-stage Parkinson’s disease Muilwijk, Danya Verheij, Simone Pel, Johan JM Boon, Agnita JW van der Steen, Johannes Transl Neurodegener Research OBJECTIVE: Many daily activities involve intrinsic or extrinsic goal-directed eye and hand movements. An extensive visuomotor coordination network including nigro-striatal pathways is required for efficient timing and positioning of eyes and hands. The aim of this study was to investigate how Parkinson’s disease (PD) affects eye-hand coordination in tasks with different cognitive complexity. METHODS: We used a touch screen, an eye-tracking device and a motion capturing system to quantify changes in eye-hand coordination in early-stage PD patients (H&Y < 2.5) and age-matched controls. Timing and kinematics of eye and hand were quantified in four eye-hand coordination tasks (pro-tapping, dual planning, anti-tapping and spatial memory task). RESULTS: In the pro-tapping task, saccade initiation towards extrinsic goals was not impaired. However, in the dual planning and anti-tapping task initiation of saccades towards intrinsic goals was faster in PD patients. Hand movements were differently affected: initiation of the hand movement was only delayed in the pro-tapping and dual planning task. Overall, hand movements in PD patients were slower executed compared to controls. INTERPRETATION: Whereas initiation of saccades in an extrinsic goal-directed task (pro-tapping task) is not affected, early stage PD patients have difficulty in suppressing reflexive saccades towards extrinsic goals in tasks where the endpoint is an intrinsic goal (e.g. dual planning and anti-tapping task). This is specific for eye movements, as hand movements have delayed responses in the pro-tapping and dual planning task. This suggests that reported impairment of the dorsolateral prefrontal cortex in early-stage PD patients affects only inhibition of eye movements. We conclude that timing and kinematics of eye and hand movements in visuomotor tasks are affected in PD patients. This result may have clinical significance by providing a behavioral marker for the early diagnosis of PD. BioMed Central 2013-01-09 /pmc/articles/PMC3563471/ /pubmed/23298720 http://dx.doi.org/10.1186/2047-9158-2-1 Text en Copyright ©2013 Muilwijk et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Muilwijk, Danya
Verheij, Simone
Pel, Johan JM
Boon, Agnita JW
van der Steen, Johannes
Changes in Timing and kinematics of goal directed eye-hand movements in early-stage Parkinson’s disease
title Changes in Timing and kinematics of goal directed eye-hand movements in early-stage Parkinson’s disease
title_full Changes in Timing and kinematics of goal directed eye-hand movements in early-stage Parkinson’s disease
title_fullStr Changes in Timing and kinematics of goal directed eye-hand movements in early-stage Parkinson’s disease
title_full_unstemmed Changes in Timing and kinematics of goal directed eye-hand movements in early-stage Parkinson’s disease
title_short Changes in Timing and kinematics of goal directed eye-hand movements in early-stage Parkinson’s disease
title_sort changes in timing and kinematics of goal directed eye-hand movements in early-stage parkinson’s disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563471/
https://www.ncbi.nlm.nih.gov/pubmed/23298720
http://dx.doi.org/10.1186/2047-9158-2-1
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