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Beyond NF-κB activation: nuclear functions of IκB kinase α

IκB kinase (IKK) complex, the master kinase for NF-κB activation, contains two kinase subunits, IKKα and IKKβ. In addition to mediating NF-κB signaling by phosphorylating IκB proteins during inflammatory and immune responses, the activation of the IKK complex also responds to various stimuli to regu...

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Autores principales: Huang, Wei-Chien, Hung, Mien-Chie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563485/
https://www.ncbi.nlm.nih.gov/pubmed/23343355
http://dx.doi.org/10.1186/1423-0127-20-3
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author Huang, Wei-Chien
Hung, Mien-Chie
author_facet Huang, Wei-Chien
Hung, Mien-Chie
author_sort Huang, Wei-Chien
collection PubMed
description IκB kinase (IKK) complex, the master kinase for NF-κB activation, contains two kinase subunits, IKKα and IKKβ. In addition to mediating NF-κB signaling by phosphorylating IκB proteins during inflammatory and immune responses, the activation of the IKK complex also responds to various stimuli to regulate diverse functions independently of NF-κB. Although these two kinases share structural and biochemical similarities, different sub-cellular localization and phosphorylation targets between IKKα and IKKβ account for their distinct physiological and pathological roles. While IKKβ is predominantly cytoplasmic, IKKα has been found to shuttle between the cytoplasm and the nucleus. The nuclear-specific roles of IKKα have brought increasing complexity to its biological function. This review highlights major advances in the studies of the nuclear functions of IKKα and the mechanisms of IKKα nuclear translocation. Understanding the nuclear activity is essential for targeting IKKα for therapeutics.
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spelling pubmed-35634852013-02-08 Beyond NF-κB activation: nuclear functions of IκB kinase α Huang, Wei-Chien Hung, Mien-Chie J Biomed Sci Review IκB kinase (IKK) complex, the master kinase for NF-κB activation, contains two kinase subunits, IKKα and IKKβ. In addition to mediating NF-κB signaling by phosphorylating IκB proteins during inflammatory and immune responses, the activation of the IKK complex also responds to various stimuli to regulate diverse functions independently of NF-κB. Although these two kinases share structural and biochemical similarities, different sub-cellular localization and phosphorylation targets between IKKα and IKKβ account for their distinct physiological and pathological roles. While IKKβ is predominantly cytoplasmic, IKKα has been found to shuttle between the cytoplasm and the nucleus. The nuclear-specific roles of IKKα have brought increasing complexity to its biological function. This review highlights major advances in the studies of the nuclear functions of IKKα and the mechanisms of IKKα nuclear translocation. Understanding the nuclear activity is essential for targeting IKKα for therapeutics. BioMed Central 2013-01-23 /pmc/articles/PMC3563485/ /pubmed/23343355 http://dx.doi.org/10.1186/1423-0127-20-3 Text en Copyright ©2013 Huang and Hung; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Huang, Wei-Chien
Hung, Mien-Chie
Beyond NF-κB activation: nuclear functions of IκB kinase α
title Beyond NF-κB activation: nuclear functions of IκB kinase α
title_full Beyond NF-κB activation: nuclear functions of IκB kinase α
title_fullStr Beyond NF-κB activation: nuclear functions of IκB kinase α
title_full_unstemmed Beyond NF-κB activation: nuclear functions of IκB kinase α
title_short Beyond NF-κB activation: nuclear functions of IκB kinase α
title_sort beyond nf-κb activation: nuclear functions of iκb kinase α
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563485/
https://www.ncbi.nlm.nih.gov/pubmed/23343355
http://dx.doi.org/10.1186/1423-0127-20-3
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