Constitutive CCND1/CDK2 Activity Substitutes for p53 Loss, or MYC or Oncogenic RAS Expression in the Transformation of Human Mammary Epithelial Cells

Cancer develops following the accumulation of genetic and epigenetic alterations that inactivate tumor suppressor genes and activate proto-oncogenes. Dysregulated cyclin-dependent kinase (CDK) activity has oncogenic potential in breast cancer due to its ability to inactivate key tumor suppressor net...

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Detalles Bibliográficos
Autores principales: Junk, Damian J., Cipriano, Rocky, Stampfer, Martha, Jackson, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563539/
https://www.ncbi.nlm.nih.gov/pubmed/23390492
http://dx.doi.org/10.1371/journal.pone.0053776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563539/
https://www.ncbi.nlm.nih.gov/pubmed/23390492
http://dx.doi.org/10.1371/journal.pone.0053776

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