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Sequential Cdk1 and Plk1 phosphorylation of protein tyrosine phosphatase 1B promotes mitotic cell death

Mitotic cell death following prolonged arrest is an important death mechanism that is not completely understood. This study shows that Protein Tyrosine Phosphatase 1B (PTP1B) undergoes phosphorylation during mitotic arrest induced by microtubule-targeting agents (MTAs) in chronic myeloid leukaemia c...

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Detalles Bibliográficos
Autores principales:	O'Donovan, D S, MacFhearraigh, S, Whitfield, J, Swigart, L B, Evan, G I, Mc Gee, M M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563996/ https://www.ncbi.nlm.nih.gov/pubmed/23348582 http://dx.doi.org/10.1038/cddis.2012.208

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