Cargando…

TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma

Tumor necrosis factor α (TNFα) and other members of the TNF family affect adipose tissue metabolism and contribute to the obesity-related inflammation of adipose tissue. Here, we sought to identify the effects of TRAIL (TNF-related apoptosis-inducing ligand) on fat cell biology. TRAIL-receptor 2 (TR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Keuper, M, Wernstedt Asterholm, I, Scherer, P E, Westhoff, M-A, Möller, P, Debatin, K-M, Strauss, G, Wabitsch, M, Fischer-Posovszky, P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563999/ https://www.ncbi.nlm.nih.gov/pubmed/23348588 http://dx.doi.org/10.1038/cddis.2012.212

Ejemplares similares

TRAIL (TNF-related apoptosis-inducing ligand) inhibits human adipocyte differentiation via caspase-mediated downregulation of adipogenic transcription factors
por: Zoller, Verena, et al.
Publicado: (2016)

Trail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes
por: Zoller, Verena, et al.
Publicado: (2017)

Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes
por: Tews, D., et al.
Publicado: (2019)

Interleukin-1β Downregulates RBP4 Secretion in Human Adipocytes
por: Kotnik, Primoz, et al.
Publicado: (2013)

THP-1 Macrophages and SGBS Adipocytes – A New Human in vitro Model System of Inflamed Adipose Tissue
por: Keuper, Michaela, et al.
Publicado: (2011)

Suppressing adipocyte inflammation promotes insulin resistance in mice
por: Zhu, Qingzhang, et al.
Publicado: (2020)

Establishment of Lipofection for Studying miRNA Function in Human Adipocytes
por: Enlund, Eveliina, et al.
Publicado: (2014)

20 Years with SGBS cells - a versatile in vitro model of human adipocyte biology
por: Tews, Daniel, et al.
Publicado: (2022)

PPARgamma Deficiency Counteracts Thymic Senescence
por: Ernszt, David, et al.
Publicado: (2017)

miR-146a-mediated suppression of the inflammatory response in human adipocytes
por: Roos, Julian, et al.
Publicado: (2016)

Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats
por: Yang, Baichun, et al.
Publicado: (2004)

Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?
por: Zinngrebe, Julia, et al.
Publicado: (2020)

NRF2 is essential for adaptative browning of white adipocytes
por: Bauzá-Thorbrügge, Marco, et al.
Publicado: (2023)

PPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice
por: Shen, B, et al.
Publicado: (2012)

Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors
por: Keuper, Michaela, et al.
Publicado: (2017)

How to Respond to Misinformation From the Anti-Vaccine Movement
por: Westhoff, Mike-Andrew, et al.
Publicado: (2023)

Clozapine modifies the differentiation program of human adipocytes inducing browning
por: Kristóf, E, et al.
Publicado: (2016)

PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action
por: Hernandez-Quiles, Miguel, et al.
Publicado: (2021)

Apoptosis induction in renal cell carcinoma by TRAIL and γ-radiation is impaired by deficient caspase-9 cleavage
por: Ramp, U, et al.
Publicado: (2003)

A SILAC-based Approach Identifies Substrates of Caspase-dependent Cleavage upon TRAIL-induced Apoptosis
por: Stoehr, Gabriele, et al.
Publicado: (2013)

Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression
por: Cantini, Giulia, et al.
Publicado: (2021)

Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis
por: Treude, Fabian, et al.
Publicado: (2014)

PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance
por: Todorov, Vladimir T.
Publicado: (2013)

Perfluorooctanesulfonate Mediates Renal Tubular Cell Apoptosis through PPARgamma Inactivation
por: Wen, Li-Li, et al.
Publicado: (2016)

Impact of X-ray Exposure on the Proliferation and Differentiation of Human Pre-Adipocytes
por: Shreder, Kateryna, et al.
Publicado: (2018)

The road to death: Caspases, cleavage, and pores
por: Dixit, Vishva M.
Publicado: (2023)

CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation
por: Dahlhaus, Meike, et al.
Publicado: (2020)

On the role of macrophages in the control of adipocyte energy metabolism
por: Keuper, Michaela
Publicado: (2019)

TRAIL-β and TRAIL-γ: two novel splice variants of the human TNF-related apoptosis-inducing ligand (TRAIL) without apoptotic potential
por: Krieg, A, et al.
Publicado: (2003)

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality
por: Demarco, Benjamin, et al.
Publicado: (2020)

PPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders
por: Grygiel-Górniak, Bogna, et al.
Publicado: (2018)

PPARgamma: A Potential Intrinsic and Extrinsic Molecular Target for Breast Cancer Therapy
por: Augimeri, Giuseppina, et al.
Publicado: (2021)

Obesity and inflammation: reduced cytokine expression due to resveratrol in a human in vitro model of inflamed adipose tissue
por: Zagotta, Ivana, et al.
Publicado: (2015)

OR20-02 Maternal Adiponectin Prevents Against Metabolic Dysfunction in Prenatally Androgenized PCOS-Like Mice
por: Benrick, Anna, et al.
Publicado: (2020)

Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage
por: Ko, Hyeonseok, et al.
Publicado: (2015)

Adipocyte-specific ablation of the Ca(2+) pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue
por: Bauzá-Thorbrügge, Marco, et al.
Publicado: (2022)

Differentiating SGBS adipocytes respond to PPARγ stimulation, irisin and BMP7 by functional browning and beige characteristics
por: Klusóczki, Ágnes, et al.
Publicado: (2019)

miR-146a regulates insulin sensitivity via NPR3
por: Roos, Julian, et al.
Publicado: (2020)

Caspase-1 interdomain linker cleavage is required for pyroptosis
por: Ball, Daniel P, et al.
Publicado: (2020)

Anti-inflammatory properties of a dual PPARgamma/alpha agonist muraglitazar in in vitro and in vivo models
por: Paukkeri, Erja-Leena, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_qmmapl0hjnnr219vsvdmf0qh18