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Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients

PURPOSE: Lymphocyte subset recovery is an important factor that determines the success of hematopoietic stem cell transplantation (HSCT). Temporal differences in the recovery of lymphocyte subsets and the factors influencing this recovery are important variables that affect a patient's post-tra...

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Autores principales: Kim, Hyun O, Oh, Hyun Jin, Lee, Jae Wook, Jang, Pil-Sang, Chung, Nack-Gyun, Cho, Bin, Kim, Hack-Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Pediatric Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564027/
https://www.ncbi.nlm.nih.gov/pubmed/23390442
http://dx.doi.org/10.3345/kjp.2013.56.1.26
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author Kim, Hyun O
Oh, Hyun Jin
Lee, Jae Wook
Jang, Pil-Sang
Chung, Nack-Gyun
Cho, Bin
Kim, Hack-Ki
author_facet Kim, Hyun O
Oh, Hyun Jin
Lee, Jae Wook
Jang, Pil-Sang
Chung, Nack-Gyun
Cho, Bin
Kim, Hack-Ki
author_sort Kim, Hyun O
collection PubMed
description PURPOSE: Lymphocyte subset recovery is an important factor that determines the success of hematopoietic stem cell transplantation (HSCT). Temporal differences in the recovery of lymphocyte subsets and the factors influencing this recovery are important variables that affect a patient's post-transplant immune reconstitution, and therefore require investigation. METHODS: The time taken to achieve lymphocyte subset recovery and the factors influencing this recovery were investigated in 59 children who had undergone HSCT at the Department of Pediatrics, The Catholic University of Korea Seoul St. Mary's Hospital, and who had an uneventful follow-up period of at least 1 year. Analyses were carried out at 3 and 12 months post-transplant. An additional study was performed 1 month post-transplant to evaluate natural killer (NK) cell recovery. The impact of pre- and post-transplant variables, including diagnosis of Epstein-Barr virus (EBV) DNAemia posttransplant, on lymphocyte recovery was evaluated. RESULTS: The lymphocyte subsets recovered in the following order: NK cells, cytotoxic T cells, B cells, and helper T cells. At 1 month post-transplant, acute graft-versus-host disease was found to contribute significantly to the delay of CD16(+)/56(+) cell recovery. Younger patients showed delayed recovery of both CD3(+)/CD8(+) and CD19(+) cells. EBV DNAemia had a deleterious impact on the recovery of both CD3(+) and CD3(+)/CD4(+) lymphocytes at 1 year post-transplant. CONCLUSION: In our pediatric allogeneic HSCT cohort, helper T cells were the last subset to recover. Younger age and EBV DNAemia had a negative impact on the post-transplant recovery of T cells and B cells.
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spelling pubmed-35640272013-02-06 Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients Kim, Hyun O Oh, Hyun Jin Lee, Jae Wook Jang, Pil-Sang Chung, Nack-Gyun Cho, Bin Kim, Hack-Ki Korean J Pediatr Original Article PURPOSE: Lymphocyte subset recovery is an important factor that determines the success of hematopoietic stem cell transplantation (HSCT). Temporal differences in the recovery of lymphocyte subsets and the factors influencing this recovery are important variables that affect a patient's post-transplant immune reconstitution, and therefore require investigation. METHODS: The time taken to achieve lymphocyte subset recovery and the factors influencing this recovery were investigated in 59 children who had undergone HSCT at the Department of Pediatrics, The Catholic University of Korea Seoul St. Mary's Hospital, and who had an uneventful follow-up period of at least 1 year. Analyses were carried out at 3 and 12 months post-transplant. An additional study was performed 1 month post-transplant to evaluate natural killer (NK) cell recovery. The impact of pre- and post-transplant variables, including diagnosis of Epstein-Barr virus (EBV) DNAemia posttransplant, on lymphocyte recovery was evaluated. RESULTS: The lymphocyte subsets recovered in the following order: NK cells, cytotoxic T cells, B cells, and helper T cells. At 1 month post-transplant, acute graft-versus-host disease was found to contribute significantly to the delay of CD16(+)/56(+) cell recovery. Younger patients showed delayed recovery of both CD3(+)/CD8(+) and CD19(+) cells. EBV DNAemia had a deleterious impact on the recovery of both CD3(+) and CD3(+)/CD4(+) lymphocytes at 1 year post-transplant. CONCLUSION: In our pediatric allogeneic HSCT cohort, helper T cells were the last subset to recover. Younger age and EBV DNAemia had a negative impact on the post-transplant recovery of T cells and B cells. The Korean Pediatric Society 2013-01 2013-01-29 /pmc/articles/PMC3564027/ /pubmed/23390442 http://dx.doi.org/10.3345/kjp.2013.56.1.26 Text en Copyright © 2013 by The Korean Pediatric Society http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Hyun O
Oh, Hyun Jin
Lee, Jae Wook
Jang, Pil-Sang
Chung, Nack-Gyun
Cho, Bin
Kim, Hack-Ki
Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients
title Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients
title_full Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients
title_fullStr Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients
title_full_unstemmed Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients
title_short Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients
title_sort immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564027/
https://www.ncbi.nlm.nih.gov/pubmed/23390442
http://dx.doi.org/10.3345/kjp.2013.56.1.26
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