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Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections

OBJECTIVE: This study tried to assess sensitivity, specificity, positive and negative predictive value of procalcitonin for diagnosis of neonatal bacterial infections. METHODS: This prospective cross sectional study was carried out during an 18-month period in NICU and neonatal wards of Besat Hospit...

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Autores principales: Monsef, Alireza, Eghbalian, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564085/
https://www.ncbi.nlm.nih.gov/pubmed/23399835
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author Monsef, Alireza
Eghbalian, Fatemeh
author_facet Monsef, Alireza
Eghbalian, Fatemeh
author_sort Monsef, Alireza
collection PubMed
description OBJECTIVE: This study tried to assess sensitivity, specificity, positive and negative predictive value of procalcitonin for diagnosis of neonatal bacterial infections. METHODS: This prospective cross sectional study was carried out during an 18-month period in NICU and neonatal wards of Besat Hospital in Hamedan province, Iran. 39 symptomatic infants with clinical and laboratory findings in favor of bacterial infection with a positive blood, CSF, and/or supra pubic urine culture entered the study; 32 newborns without any bacterial infection served as control group. Quantitative procalcitonin level ≥0.5 ng/ml was accepted as pathological. Finally sensitivity, specificity, positive (PPV) and negative predictive value (NPV) were calculated for procalcitonin test. FINDINGS: 20 blood cultures, 17 urine cultures and 8 CSF cultures were positive. Sensitivity, specificity, PPV and NPV for procalcitonin test was 76.9%, 100%, 100% and 78% respectively. Diagnostic value of procalcitonin test in accordance with blood culture for mentioned items was 85%, 100%, 100% and 91.4% respectively. Its diagnostic value according to urine culture was: sensitivity 70.6%, specificity 100%, PPV 100% and NPV 86.4%, and according to CSF culture was: sensitivity 75%, specificity 100%, PPV 100% and NPV 94.1% respectively. CONCLUSION: The results show that the procalcitonin test has high sensitivity, specificity, PPV and NPV for diagnosis of neonatal infections.
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spelling pubmed-35640852013-02-10 Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections Monsef, Alireza Eghbalian, Fatemeh Iran J Pediatr Original Article OBJECTIVE: This study tried to assess sensitivity, specificity, positive and negative predictive value of procalcitonin for diagnosis of neonatal bacterial infections. METHODS: This prospective cross sectional study was carried out during an 18-month period in NICU and neonatal wards of Besat Hospital in Hamedan province, Iran. 39 symptomatic infants with clinical and laboratory findings in favor of bacterial infection with a positive blood, CSF, and/or supra pubic urine culture entered the study; 32 newborns without any bacterial infection served as control group. Quantitative procalcitonin level ≥0.5 ng/ml was accepted as pathological. Finally sensitivity, specificity, positive (PPV) and negative predictive value (NPV) were calculated for procalcitonin test. FINDINGS: 20 blood cultures, 17 urine cultures and 8 CSF cultures were positive. Sensitivity, specificity, PPV and NPV for procalcitonin test was 76.9%, 100%, 100% and 78% respectively. Diagnostic value of procalcitonin test in accordance with blood culture for mentioned items was 85%, 100%, 100% and 91.4% respectively. Its diagnostic value according to urine culture was: sensitivity 70.6%, specificity 100%, PPV 100% and NPV 86.4%, and according to CSF culture was: sensitivity 75%, specificity 100%, PPV 100% and NPV 94.1% respectively. CONCLUSION: The results show that the procalcitonin test has high sensitivity, specificity, PPV and NPV for diagnosis of neonatal infections. Tehran University of Medical Sciences 2012-09 /pmc/articles/PMC3564085/ /pubmed/23399835 Text en © 2012 Iranian Journal of Pediatrics & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Monsef, Alireza
Eghbalian, Fatemeh
Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections
title Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections
title_full Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections
title_fullStr Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections
title_full_unstemmed Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections
title_short Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections
title_sort evaluation of diagnostic value of procalcitonin as a marker of neonatal bacterial infections
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564085/
https://www.ncbi.nlm.nih.gov/pubmed/23399835
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