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Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections
OBJECTIVE: This study tried to assess sensitivity, specificity, positive and negative predictive value of procalcitonin for diagnosis of neonatal bacterial infections. METHODS: This prospective cross sectional study was carried out during an 18-month period in NICU and neonatal wards of Besat Hospit...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564085/ https://www.ncbi.nlm.nih.gov/pubmed/23399835 |
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author | Monsef, Alireza Eghbalian, Fatemeh |
author_facet | Monsef, Alireza Eghbalian, Fatemeh |
author_sort | Monsef, Alireza |
collection | PubMed |
description | OBJECTIVE: This study tried to assess sensitivity, specificity, positive and negative predictive value of procalcitonin for diagnosis of neonatal bacterial infections. METHODS: This prospective cross sectional study was carried out during an 18-month period in NICU and neonatal wards of Besat Hospital in Hamedan province, Iran. 39 symptomatic infants with clinical and laboratory findings in favor of bacterial infection with a positive blood, CSF, and/or supra pubic urine culture entered the study; 32 newborns without any bacterial infection served as control group. Quantitative procalcitonin level ≥0.5 ng/ml was accepted as pathological. Finally sensitivity, specificity, positive (PPV) and negative predictive value (NPV) were calculated for procalcitonin test. FINDINGS: 20 blood cultures, 17 urine cultures and 8 CSF cultures were positive. Sensitivity, specificity, PPV and NPV for procalcitonin test was 76.9%, 100%, 100% and 78% respectively. Diagnostic value of procalcitonin test in accordance with blood culture for mentioned items was 85%, 100%, 100% and 91.4% respectively. Its diagnostic value according to urine culture was: sensitivity 70.6%, specificity 100%, PPV 100% and NPV 86.4%, and according to CSF culture was: sensitivity 75%, specificity 100%, PPV 100% and NPV 94.1% respectively. CONCLUSION: The results show that the procalcitonin test has high sensitivity, specificity, PPV and NPV for diagnosis of neonatal infections. |
format | Online Article Text |
id | pubmed-3564085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-35640852013-02-10 Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections Monsef, Alireza Eghbalian, Fatemeh Iran J Pediatr Original Article OBJECTIVE: This study tried to assess sensitivity, specificity, positive and negative predictive value of procalcitonin for diagnosis of neonatal bacterial infections. METHODS: This prospective cross sectional study was carried out during an 18-month period in NICU and neonatal wards of Besat Hospital in Hamedan province, Iran. 39 symptomatic infants with clinical and laboratory findings in favor of bacterial infection with a positive blood, CSF, and/or supra pubic urine culture entered the study; 32 newborns without any bacterial infection served as control group. Quantitative procalcitonin level ≥0.5 ng/ml was accepted as pathological. Finally sensitivity, specificity, positive (PPV) and negative predictive value (NPV) were calculated for procalcitonin test. FINDINGS: 20 blood cultures, 17 urine cultures and 8 CSF cultures were positive. Sensitivity, specificity, PPV and NPV for procalcitonin test was 76.9%, 100%, 100% and 78% respectively. Diagnostic value of procalcitonin test in accordance with blood culture for mentioned items was 85%, 100%, 100% and 91.4% respectively. Its diagnostic value according to urine culture was: sensitivity 70.6%, specificity 100%, PPV 100% and NPV 86.4%, and according to CSF culture was: sensitivity 75%, specificity 100%, PPV 100% and NPV 94.1% respectively. CONCLUSION: The results show that the procalcitonin test has high sensitivity, specificity, PPV and NPV for diagnosis of neonatal infections. Tehran University of Medical Sciences 2012-09 /pmc/articles/PMC3564085/ /pubmed/23399835 Text en © 2012 Iranian Journal of Pediatrics & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Monsef, Alireza Eghbalian, Fatemeh Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections |
title | Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections |
title_full | Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections |
title_fullStr | Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections |
title_full_unstemmed | Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections |
title_short | Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections |
title_sort | evaluation of diagnostic value of procalcitonin as a marker of neonatal bacterial infections |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564085/ https://www.ncbi.nlm.nih.gov/pubmed/23399835 |
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