Insights into the Roles of Cyclophilin A During Influenza Virus Infection

Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the replication of several viruses. Upon influenz...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xiaoling, Zhao, Zhendong, Liu, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564116/
https://www.ncbi.nlm.nih.gov/pubmed/23322171
http://dx.doi.org/10.3390/v5010182
_version_ 1782258281891233792
author Liu, Xiaoling
Zhao, Zhendong
Liu, Wenjun
author_facet Liu, Xiaoling
Zhao, Zhendong
Liu, Wenjun
author_sort Liu, Xiaoling
collection PubMed
description Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the replication of several viruses. Upon influenza virus infection, CypA inhibits viral replication by interacting with the M1 protein. In addition, CypA is incorporated into the influenza virus virions. Finally, Cyclosporin A (CsA), the main inhibitor of CypA, inhibits influenza virus replication through CypA-dependent and -independent pathways. This review briefly summarizes recent advances in understanding the roles of CypA during influenza virus infection.
format Online
Article
Text
id pubmed-3564116
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-35641162013-02-11 Insights into the Roles of Cyclophilin A During Influenza Virus Infection Liu, Xiaoling Zhao, Zhendong Liu, Wenjun Viruses Review Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the replication of several viruses. Upon influenza virus infection, CypA inhibits viral replication by interacting with the M1 protein. In addition, CypA is incorporated into the influenza virus virions. Finally, Cyclosporin A (CsA), the main inhibitor of CypA, inhibits influenza virus replication through CypA-dependent and -independent pathways. This review briefly summarizes recent advances in understanding the roles of CypA during influenza virus infection. MDPI 2013-01-15 /pmc/articles/PMC3564116/ /pubmed/23322171 http://dx.doi.org/10.3390/v5010182 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Liu, Xiaoling
Zhao, Zhendong
Liu, Wenjun
Insights into the Roles of Cyclophilin A During Influenza Virus Infection
title Insights into the Roles of Cyclophilin A During Influenza Virus Infection
title_full Insights into the Roles of Cyclophilin A During Influenza Virus Infection
title_fullStr Insights into the Roles of Cyclophilin A During Influenza Virus Infection
title_full_unstemmed Insights into the Roles of Cyclophilin A During Influenza Virus Infection
title_short Insights into the Roles of Cyclophilin A During Influenza Virus Infection
title_sort insights into the roles of cyclophilin a during influenza virus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564116/
https://www.ncbi.nlm.nih.gov/pubmed/23322171
http://dx.doi.org/10.3390/v5010182
work_keys_str_mv AT liuxiaoling insightsintotherolesofcyclophilinaduringinfluenzavirusinfection
AT zhaozhendong insightsintotherolesofcyclophilinaduringinfluenzavirusinfection
AT liuwenjun insightsintotherolesofcyclophilinaduringinfluenzavirusinfection

Ejemplares similares