Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus

Epstein-Barr Nuclear Antigen 1 (EBNA1) is a multifunctional protein encoded by EBV. EBNA1’s role in maintaining EBV in latently proliferating cells, by mediating EBV genome synthesis and nonrandom partitioning to daughter cells, as well as regulating viral gene transcription, is well characterized....

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Danielle Westhoff, Sugden, Bill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564119/
https://www.ncbi.nlm.nih.gov/pubmed/23325328
http://dx.doi.org/10.3390/v5010226
_version_ 1782258282608459776
author Smith, Danielle Westhoff
Sugden, Bill
author_facet Smith, Danielle Westhoff
Sugden, Bill
author_sort Smith, Danielle Westhoff
collection PubMed
description Epstein-Barr Nuclear Antigen 1 (EBNA1) is a multifunctional protein encoded by EBV. EBNA1’s role in maintaining EBV in latently proliferating cells, by mediating EBV genome synthesis and nonrandom partitioning to daughter cells, as well as regulating viral gene transcription, is well characterized. Less understood are the roles of EBNA1 in affecting the host cell to provide selective advantages to those cells that harbor EBV. In this review we will focus on the interactions between EBNA1 and the host cell that may provide EBV-infected cells selective advantages beyond the maintenance of EBV.
format Online
Article
Text
id pubmed-3564119
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-35641192013-02-11 Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus Smith, Danielle Westhoff Sugden, Bill Viruses Review Epstein-Barr Nuclear Antigen 1 (EBNA1) is a multifunctional protein encoded by EBV. EBNA1’s role in maintaining EBV in latently proliferating cells, by mediating EBV genome synthesis and nonrandom partitioning to daughter cells, as well as regulating viral gene transcription, is well characterized. Less understood are the roles of EBNA1 in affecting the host cell to provide selective advantages to those cells that harbor EBV. In this review we will focus on the interactions between EBNA1 and the host cell that may provide EBV-infected cells selective advantages beyond the maintenance of EBV. MDPI 2013-01-16 /pmc/articles/PMC3564119/ /pubmed/23325328 http://dx.doi.org/10.3390/v5010226 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Smith, Danielle Westhoff
Sugden, Bill
Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus
title Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus
title_full Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus
title_fullStr Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus
title_full_unstemmed Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus
title_short Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus
title_sort potential cellular functions of epstein-barr nuclear antigen 1 (ebna1) of epstein-barr virus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564119/
https://www.ncbi.nlm.nih.gov/pubmed/23325328
http://dx.doi.org/10.3390/v5010226
work_keys_str_mv AT smithdaniellewesthoff potentialcellularfunctionsofepsteinbarrnuclearantigen1ebna1ofepsteinbarrvirus
AT sugdenbill potentialcellularfunctionsofepsteinbarrnuclearantigen1ebna1ofepsteinbarrvirus

Ejemplares similares