Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov

One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2–6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indo...

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Autores principales: Yang, Xian-Wen, Zhang, Gai-Yun, Ying, Jian-Xi, Yang, Bing, Zhou, Xue-Feng, Steinmetz, Andre, Liu, Yong-Hong, Wang, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564155/
https://www.ncbi.nlm.nih.gov/pubmed/23271423
http://dx.doi.org/10.3390/md11010033
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author Yang, Xian-Wen
Zhang, Gai-Yun
Ying, Jian-Xi
Yang, Bing
Zhou, Xue-Feng
Steinmetz, Andre
Liu, Yong-Hong
Wang, Ning
author_facet Yang, Xian-Wen
Zhang, Gai-Yun
Ying, Jian-Xi
Yang, Bing
Zhou, Xue-Feng
Steinmetz, Andre
Liu, Yong-Hong
Wang, Ning
author_sort Yang, Xian-Wen
collection PubMed
description One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2–6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).
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spelling pubmed-35641552013-02-11 Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov Yang, Xian-Wen Zhang, Gai-Yun Ying, Jian-Xi Yang, Bing Zhou, Xue-Feng Steinmetz, Andre Liu, Yong-Hong Wang, Ning Mar Drugs Communication One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2–6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702). MDPI 2012-12-27 /pmc/articles/PMC3564155/ /pubmed/23271423 http://dx.doi.org/10.3390/md11010033 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Yang, Xian-Wen
Zhang, Gai-Yun
Ying, Jian-Xi
Yang, Bing
Zhou, Xue-Feng
Steinmetz, Andre
Liu, Yong-Hong
Wang, Ning
Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov
title Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov
title_full Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov
title_fullStr Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov
title_full_unstemmed Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov
title_short Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov
title_sort isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl)methyl)-1h-indole, a new alkaloid from a deep-sea-derived actinomycete serinicoccus profundi sp. nov
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564155/
https://www.ncbi.nlm.nih.gov/pubmed/23271423
http://dx.doi.org/10.3390/md11010033
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