Cargando…

PKM and the maintenance of memory

How can memories outlast the molecules from which they are made? Answers to this fundamental question have been slow coming but are now emerging. A novel kinase, an isoform of protein kinase C (PKC), PKMzeta, has been shown to be critical to the maintenance of some types of memory. Inhibiting the ca...

Descripción completa

Detalles Bibliográficos
Autor principal: Glanzman, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564217/
https://www.ncbi.nlm.nih.gov/pubmed/23413372
http://dx.doi.org/10.3410/B5-4
_version_ 1782258299748483072
author Glanzman, David L.
author_facet Glanzman, David L.
author_sort Glanzman, David L.
collection PubMed
description How can memories outlast the molecules from which they are made? Answers to this fundamental question have been slow coming but are now emerging. A novel kinase, an isoform of protein kinase C (PKC), PKMzeta, has been shown to be critical to the maintenance of some types of memory. Inhibiting the catalytic properties of this kinase can erase well-established memories without altering the ability of the erased synapse to be retrained. This article provides an overview of the literature linking PKMzeta to memory maintenance and identifies some of the controversial issues that surround the bold implications of the existing data. It concludes with a discussion of the future directions of this domain.
format Online
Article
Text
id pubmed-3564217
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Faculty of 1000 Ltd
record_format MEDLINE/PubMed
spelling pubmed-35642172013-02-14 PKM and the maintenance of memory Glanzman, David L. F1000 Biol Rep Review Article How can memories outlast the molecules from which they are made? Answers to this fundamental question have been slow coming but are now emerging. A novel kinase, an isoform of protein kinase C (PKC), PKMzeta, has been shown to be critical to the maintenance of some types of memory. Inhibiting the catalytic properties of this kinase can erase well-established memories without altering the ability of the erased synapse to be retrained. This article provides an overview of the literature linking PKMzeta to memory maintenance and identifies some of the controversial issues that surround the bold implications of the existing data. It concludes with a discussion of the future directions of this domain. Faculty of 1000 Ltd 2013-02-01 /pmc/articles/PMC3564217/ /pubmed/23413372 http://dx.doi.org/10.3410/B5-4 Text en © 2013 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Glanzman, David L.
PKM and the maintenance of memory
title PKM and the maintenance of memory
title_full PKM and the maintenance of memory
title_fullStr PKM and the maintenance of memory
title_full_unstemmed PKM and the maintenance of memory
title_short PKM and the maintenance of memory
title_sort pkm and the maintenance of memory
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564217/
https://www.ncbi.nlm.nih.gov/pubmed/23413372
http://dx.doi.org/10.3410/B5-4
work_keys_str_mv AT glanzmandavidl pkmandthemaintenanceofmemory