A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation

Spatial control of RhoGTPase-inactivating GAP components remains largely enigmatic. We describe a brain-specific RhoGAP splice variant, BARGIN (BGIN), which comprises a combination of BAR, GAP, and partial CIN phosphatase domains spliced from adjacent SH3BP1 and CIN gene loci. Excision of BGIN exon...

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Detalles Bibliográficos
Autores principales: Huang, Timothy Y., Michael, Sarah, Xu, Tao, Sarkeshik, Ali, Moresco, James J., Yates, John R., Masliah, Eliezer, Bokoch, Gary M., DerMardirossian, Céline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564530/
https://www.ncbi.nlm.nih.gov/pubmed/23223568
http://dx.doi.org/10.1091/mbc.E12-07-0565

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