Surprisingly high number of Twintrons in vertebrates

Twintrons represent a special intronic arrangement in which introns of two different types occupy the same gene position. Consequently, alternative splicing of these introns requires two different spliceosomes competing for the same RNA molecule. So far, only two twintrons have been described in ins...

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Detalles Bibliográficos
Autores principales: Janice, Jessin, Jąkalski, Marcin, Makałowski, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Discovery Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564746/
https://www.ncbi.nlm.nih.gov/pubmed/23356793
http://dx.doi.org/10.1186/1745-6150-8-4
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author Janice, Jessin
Jąkalski, Marcin
Makałowski, Wojciech
author_facet Janice, Jessin
Jąkalski, Marcin
Makałowski, Wojciech
author_sort Janice, Jessin
collection PubMed
description Twintrons represent a special intronic arrangement in which introns of two different types occupy the same gene position. Consequently, alternative splicing of these introns requires two different spliceosomes competing for the same RNA molecule. So far, only two twintrons have been described in insects. Surprisingly, we discovered several such arrangements in vertebrate genomes, which are quite conserved throughout the lineages. REVIEWERS: This article was reviewed by Fyodor Kondrashow and Eugene Koonin.
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spelling pubmed-35647462013-02-08 Surprisingly high number of Twintrons in vertebrates Janice, Jessin Jąkalski, Marcin Makałowski, Wojciech Biol Direct Discovery Notes Twintrons represent a special intronic arrangement in which introns of two different types occupy the same gene position. Consequently, alternative splicing of these introns requires two different spliceosomes competing for the same RNA molecule. So far, only two twintrons have been described in insects. Surprisingly, we discovered several such arrangements in vertebrate genomes, which are quite conserved throughout the lineages. REVIEWERS: This article was reviewed by Fyodor Kondrashow and Eugene Koonin. BioMed Central 2013-01-28 /pmc/articles/PMC3564746/ /pubmed/23356793 http://dx.doi.org/10.1186/1745-6150-8-4 Text en Copyright ©2013 Janice et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Discovery Notes
Janice, Jessin
Jąkalski, Marcin
Makałowski, Wojciech
Surprisingly high number of Twintrons in vertebrates
title Surprisingly high number of Twintrons in vertebrates
title_full Surprisingly high number of Twintrons in vertebrates
title_fullStr Surprisingly high number of Twintrons in vertebrates
title_full_unstemmed Surprisingly high number of Twintrons in vertebrates
title_short Surprisingly high number of Twintrons in vertebrates
title_sort surprisingly high number of twintrons in vertebrates
topic Discovery Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564746/
https://www.ncbi.nlm.nih.gov/pubmed/23356793
http://dx.doi.org/10.1186/1745-6150-8-4
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