A Compensatory Mutation Provides Resistance to Disparate HIV Fusion Inhibitor Peptides and Enhances Membrane Fusion

Fusion inhibitors are a class of antiretroviral drugs used to prevent entry of HIV into host cells. Many of the fusion inhibitors being developed, including the drug enfuvirtide, are peptides designed to competitively inhibit the viral fusion protein gp41. With the emergence of drug resistance, ther...

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Detalles Bibliográficos
Autores principales: Wood, Matthew P., Cole, Amy L., Ruchala, Piotr, Waring, Alan J., Rohan, Lisa C., Marx, Preston, Tarwater, Patrick M., Gupta, Phalguni, Cole, Alexander M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564752/
https://www.ncbi.nlm.nih.gov/pubmed/23393582
http://dx.doi.org/10.1371/journal.pone.0055478

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