The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression

Transforming growth factor (TGF)-β/Smad signaling plays an important role in colon cancer development, progression and metastasis. In this study we demonstrated that the microRNA-130a/301a/454 family is up-regulated in colon cancer tissues compared to paired adjacent normal mucosa, which share the s...

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Autores principales: Liu, Lin, Nie, Jing, Chen, Lin, Dong, Guanglong, Du, Xiaohui, Wu, Xin, Tang, Yun, Han, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564758/
https://www.ncbi.nlm.nih.gov/pubmed/23393589
http://dx.doi.org/10.1371/journal.pone.0055532
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author Liu, Lin
Nie, Jing
Chen, Lin
Dong, Guanglong
Du, Xiaohui
Wu, Xin
Tang, Yun
Han, Weidong
author_facet Liu, Lin
Nie, Jing
Chen, Lin
Dong, Guanglong
Du, Xiaohui
Wu, Xin
Tang, Yun
Han, Weidong
author_sort Liu, Lin
collection PubMed
description Transforming growth factor (TGF)-β/Smad signaling plays an important role in colon cancer development, progression and metastasis. In this study we demonstrated that the microRNA-130a/301a/454 family is up-regulated in colon cancer tissues compared to paired adjacent normal mucosa, which share the same 3′-untranslational region (3′-UTR) binding seed sequence and are predicated to target Smad4. In colorectal cancer HCT116 and SW480 cells, overexpression of miRNA-130a/301a/454 mimics enhances cell proliferation and migration, while inhibitors of these miRNAs affect cell survival. The biological function of miRNA-130a/301a/454 on colon cancer cells is likely mediated by suppression of Smad4, and the up-regulation of the miRNAs is correlated with Smad4 down-regulation in human colon cancers. Collectively, these results suggest that miRNA-130a/301a/454 are novel oncogenic miRNAs contributing to colon tumorigenesis by regulating TGF-β/Smad signaling, which may have potential application in cancer therapy.
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spelling pubmed-35647582013-02-07 The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression Liu, Lin Nie, Jing Chen, Lin Dong, Guanglong Du, Xiaohui Wu, Xin Tang, Yun Han, Weidong PLoS One Research Article Transforming growth factor (TGF)-β/Smad signaling plays an important role in colon cancer development, progression and metastasis. In this study we demonstrated that the microRNA-130a/301a/454 family is up-regulated in colon cancer tissues compared to paired adjacent normal mucosa, which share the same 3′-untranslational region (3′-UTR) binding seed sequence and are predicated to target Smad4. In colorectal cancer HCT116 and SW480 cells, overexpression of miRNA-130a/301a/454 mimics enhances cell proliferation and migration, while inhibitors of these miRNAs affect cell survival. The biological function of miRNA-130a/301a/454 on colon cancer cells is likely mediated by suppression of Smad4, and the up-regulation of the miRNAs is correlated with Smad4 down-regulation in human colon cancers. Collectively, these results suggest that miRNA-130a/301a/454 are novel oncogenic miRNAs contributing to colon tumorigenesis by regulating TGF-β/Smad signaling, which may have potential application in cancer therapy. Public Library of Science 2013-02-05 /pmc/articles/PMC3564758/ /pubmed/23393589 http://dx.doi.org/10.1371/journal.pone.0055532 Text en © 2013 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Liu, Lin
Nie, Jing
Chen, Lin
Dong, Guanglong
Du, Xiaohui
Wu, Xin
Tang, Yun
Han, Weidong
The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression
title The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression
title_full The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression
title_fullStr The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression
title_full_unstemmed The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression
title_short The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression
title_sort oncogenic role of microrna-130a/301a/454 in human colorectal cancer via targeting smad4 expression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564758/
https://www.ncbi.nlm.nih.gov/pubmed/23393589
http://dx.doi.org/10.1371/journal.pone.0055532
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