Non-Invasive Imaging of Phosphoinositide-3-Kinase-Catalytic-Subunit-Alpha (PIK3CA) Promoter Modulation in Small Animal Models

Activation of the PI3K/Akt pathway, a critical step for survival in cancer cells is often associated with decreased sensitivity to several chemotherapeutic drugs. PIK3CA gene amplification is observed in 16–24% of epithelial ovarian cancer (EOC) patients in conjunction with p53 mutations. A 900 bp l...

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Detalles Bibliográficos
Autores principales: Gaikwad, Snehal M., Gunjal, Lata, Junutula, Anitha R., Astanehe, Arezoo, Gambhir, Sanjiv Sam, Ray, Pritha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564913/
https://www.ncbi.nlm.nih.gov/pubmed/23393606
http://dx.doi.org/10.1371/journal.pone.0055971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564913/
https://www.ncbi.nlm.nih.gov/pubmed/23393606
http://dx.doi.org/10.1371/journal.pone.0055971

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