Genome-Wide Copy Number Variant Analysis in Inbred Chickens Lines With Different Susceptibility to Marek’s Disease

Breeding of genetically resistant chickens to Marek’s disease (MD) is a vital strategy to poultry health. To find the markers underlying the genetic resistance to MD, copy number variation (CNV) was examined in inbred MD-resistant and -susceptible chicken lines. A total of 45 CNVs were found in four...

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Autores principales: Luo, Juan, Yu, Ying, Mitra, Apratim, Chang, Shuang, Zhang, Huanmin, Liu, George, Yang, Ning, Song, Jiuzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2013
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564982/
https://www.ncbi.nlm.nih.gov/pubmed/23390598
http://dx.doi.org/10.1534/g3.112.005132
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author Luo, Juan
Yu, Ying
Mitra, Apratim
Chang, Shuang
Zhang, Huanmin
Liu, George
Yang, Ning
Song, Jiuzhou
author_facet Luo, Juan
Yu, Ying
Mitra, Apratim
Chang, Shuang
Zhang, Huanmin
Liu, George
Yang, Ning
Song, Jiuzhou
author_sort Luo, Juan
collection PubMed
description Breeding of genetically resistant chickens to Marek’s disease (MD) is a vital strategy to poultry health. To find the markers underlying the genetic resistance to MD, copy number variation (CNV) was examined in inbred MD-resistant and -susceptible chicken lines. A total of 45 CNVs were found in four lines of chickens, and 28 were potentially involved in immune response and cell proliferation, etc. Importantly, two CNVs related with MD resistance were transmitted to descendent recombinant congenic lines that differ in susceptibility to MD. Our findings may lead to better strategies for genetic improvement of disease resistance in poultry.
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spelling pubmed-35649822013-02-06 Genome-Wide Copy Number Variant Analysis in Inbred Chickens Lines With Different Susceptibility to Marek’s Disease Luo, Juan Yu, Ying Mitra, Apratim Chang, Shuang Zhang, Huanmin Liu, George Yang, Ning Song, Jiuzhou G3 (Bethesda) Investigations Breeding of genetically resistant chickens to Marek’s disease (MD) is a vital strategy to poultry health. To find the markers underlying the genetic resistance to MD, copy number variation (CNV) was examined in inbred MD-resistant and -susceptible chicken lines. A total of 45 CNVs were found in four lines of chickens, and 28 were potentially involved in immune response and cell proliferation, etc. Importantly, two CNVs related with MD resistance were transmitted to descendent recombinant congenic lines that differ in susceptibility to MD. Our findings may lead to better strategies for genetic improvement of disease resistance in poultry. Genetics Society of America 2013-02-01 /pmc/articles/PMC3564982/ /pubmed/23390598 http://dx.doi.org/10.1534/g3.112.005132 Text en Copyright © 2013 Luo et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Investigations
Luo, Juan
Yu, Ying
Mitra, Apratim
Chang, Shuang
Zhang, Huanmin
Liu, George
Yang, Ning
Song, Jiuzhou
Genome-Wide Copy Number Variant Analysis in Inbred Chickens Lines With Different Susceptibility to Marek’s Disease
title Genome-Wide Copy Number Variant Analysis in Inbred Chickens Lines With Different Susceptibility to Marek’s Disease
title_full Genome-Wide Copy Number Variant Analysis in Inbred Chickens Lines With Different Susceptibility to Marek’s Disease
title_fullStr Genome-Wide Copy Number Variant Analysis in Inbred Chickens Lines With Different Susceptibility to Marek’s Disease
title_full_unstemmed Genome-Wide Copy Number Variant Analysis in Inbred Chickens Lines With Different Susceptibility to Marek’s Disease
title_short Genome-Wide Copy Number Variant Analysis in Inbred Chickens Lines With Different Susceptibility to Marek’s Disease
title_sort genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to marek’s disease
topic Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564982/
https://www.ncbi.nlm.nih.gov/pubmed/23390598
http://dx.doi.org/10.1534/g3.112.005132
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