Sequential Primed Kinases Create a Damage-Responsive Phosphodegron on Eco1

Sister-chromatid cohesion is established during S phase when Eco1 acetylates cohesin. In budding yeast, Eco1 activity falls after S phase due to Cdk1-dependent phosphorylation, which triggers ubiquitination by SCF-Cdc4. We show here that Eco1 degradation requires the sequential actions of Cdk1 and t...

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Detalles Bibliográficos
Autores principales: Lyons, Nicholas A., Fonslow, Bryan R., Diedrich, Jolene K., Yates, John R., Morgan, David O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565030/
https://www.ncbi.nlm.nih.gov/pubmed/23314252
http://dx.doi.org/10.1038/nsmb.2478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565030/
https://www.ncbi.nlm.nih.gov/pubmed/23314252
http://dx.doi.org/10.1038/nsmb.2478

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