Cargando…
Sequential Primed Kinases Create a Damage-Responsive Phosphodegron on Eco1
Sister-chromatid cohesion is established during S phase when Eco1 acetylates cohesin. In budding yeast, Eco1 activity falls after S phase due to Cdk1-dependent phosphorylation, which triggers ubiquitination by SCF-Cdc4. We show here that Eco1 degradation requires the sequential actions of Cdk1 and t...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565030/ https://www.ncbi.nlm.nih.gov/pubmed/23314252 http://dx.doi.org/10.1038/nsmb.2478 |